Li [15] 2014 China | Mean Age of Cases NR N = 3: F = NR, M = NR Mean Age of Controls NR N = 3: F = NR, M = NR Ethnic status: NR | Synovial chondromatosis for cases; Open Reduction for controls NR | FGF2 | FGF2 was involved in the pathogenesis of synovial chondromatosis (P < 0.01) | NR |
Yamaguchi [22] 2015 Japan | Mean Age of Cases Japanese 25.6 Koreans 28.5 N of Japanese = 105: F = 93, M = 12 N of Koreans = 41: F = 23, M = 18 Mean Age of Controls Japanese 25.6 Koreans 28.5 N of Japanese = 193 F = 141, M = 53 N of Koreans = 181 F = 70, M = 111) Ethnic status: East Asian | Osteophytes, erosion, flattening of TMJ bone Interview, CT, MRI, Panoramic Radiograph | APOL3 APP CCDC81 EXT2 FRMD4A FSTL4 LOC100506274 MRC2 N4BP1 OXR1 PCSK5 SLC24A4 THRB TPSAN9 ULK4 ZNF618 | All the genes were found to be significantly associated. TSPAN9 showed strongest association (P = 8.1 × 10−6) | Small sample size, age and gender differed between Japanese and Korean data sets |
Etoz [20] 2006 Turkey | Mean Age of Cases 21.1 ± 12.1 N = 98; F = 75, M = 23 Mean Age of Controls 22.9 ± 10.1 N = 132: F = 104, M = 28 Ethnic Status: Turkish | Difficulty or pain while opening mouth, locking of jaw, pain, noises, unusual bite, frequent headache, MRI findings-NR Anamnestic Questionnaire clinical investigation, MRI | TNF | TNFα-308GApolymorphism is not associated with TMD | NR No radiological diagnosis |
Mutlu [16] 2005 Turkey | Mean Age of Cases: 22.8 ± 3.6 years; N = 93; F = 73, M = 20 Mean Age of Controls 21.10 ± 3.7 N = 91: F = 61, M = 30 Ethnic Status: NR | Difficulty or pain while opening mouth, locking of jaw, pain, noises, unusual bite, frequent headache, MRI findings-NR Anamnestic Questionnaire clinical investigation, MRI | MAOA | No evidence to support the involvement of MAOA gene in TMD | NR No radiological diagnosis |