Subfamily | Structure | Features | Activities | |
NMR | Crystal | |||
DD | Fas DD FADD DD TNFR1 DD P75 DD | IRAK4 DD RAIDD DD | Variation exist in length and direction of helices Sequence homology low | Homotypic interactions Form homodimers Use to assemble signal complexes intracellularly for activation of caspase and NF-кB |
DED | FADD DED PEA-15 DED | MC159 DED1 MC159 DED2 | H2 residues form a hydrophobic patch E/D-RxDL motif form a conserved hydrogen-bonded charge | Found on caspases and adapters Induce apoptosis (DED containing caspase) NF-кB signalling Induce or inhibit caspase activation |
CARD | RAIDD CARD ICEBERG CARD
| Apaf-1 | H1 either bent or broken into H1a and H1b helices Have polarized surface for interactions. | Apoptosis Cytokine processing Immune defense NF-кB activation |
PYD | NALP1 PYD ASC PYD | NONE | H3 is altered replace by flexible loop | Probable caspase activation Function not really understood |