Brain region

Tg2576 mice

dE9 mice

Normal mice

n.c.a.^a [¹⁸F]FDDNP

20 mg FDDNP carrier

200 mg FDDNP carrier

n.c.a. [¹⁸F]FDDNP

200 mg FDDNP carrier

20 mg FDDNP carrier

n.c.a. [¹⁸F]FDDNP

20 mg FDDNP carrier

200 mg FDDNP carrier

Cortex

109.79 ± 25.33

87.52 ± 22.48

33.92 ± 11.98^*

27.41 ± 4.47^○

6.63 ± 1.87^*

4.77 ± 2.04^*

7.19 ± 1.81

5.63 ± 0.73

2.44 ± 0.57

Hippocampus

49.15 ± 13.50⁺

34.16 ± 11.40

23.31 ± 9.30

8.71 ± 4.02

2.00 ± 1.08

1.65 ± 0.76

4.05 ± 1.04

4.74 ± 1.54

2.14 ± 1.08

Thalamus

73.07 ± 16.73⁺

28.94 ± 14.06^*

17.75 ± 8.78^*

9.73 ± 1.89

1.37 ± 0.39^*

2.65 ± 1.02^*

9.54 ± 1.98

4.52 ± 1.57^*

10.33 ± 3.00

Hypothalamus

44.14 ± 15.02⁺

32.31 ± 8.02

19.44 ± 8.19^*

8.25 ± 0.76

1.20 ± 0.84^*

1.26 ± 0.78^*

5.87 ± 1.20

4.35 ± 1.93

4.06 ± 1.27

Midbrain

39.39 ± 13.99⁺

28.51 ± 10.68

20.54 ± 0.76

6.72 ± 3.61

0.90 ± 0.34

3.82 ± 1.91

1.26 ± 1.14

8.36 ± 1.65^*

2.43 ± 1.51

Pons

38.28 ± 15.53

24.97 ± 7.24

20.08 ± 11.06^*

6.00 ± 2.04

1.87 ± 0.91^*

0.02 ± 0.01^*

5.43 ± 1.99

10.17 ± 4.98

3.50 ± 1.42

Medulla

38.61 ± 13.67⁺

28.57 ± 8.97

23.43 ± 13.96

8.33 ± 1.70

1.63 ± 1.01^*

3.23 ± 1.20^*

9.55 ± 2.83

1.49 ± 0.74

0.17 ± 0.10^*

Cerebellum

115.50 ± 33.25

110.78 ± 27.45

48.93 ± 16.63

22.01 ± 13.54

12.36 ± 6.59

11.44 ± 4.24

22.70 ± 6.34

3.49 ± 1.59^*

21.89 ± 12.11