Grades

Toxicities

Grade 1

A mild or minimal adverse event, usually asymptomatic, that does not interfere with any function and does not require treatment or intervention

Grade 2

Moderate adverse event, usually symptomatic, requiring interventions such as local treatments, they may or may not interfere with function but not interfere with activities of daily living

Grade 3

Severe adverse event requiring serious interventions or even hospitalization

Grade 4

Life-threatening or disabling adverse event; disability

Grade 5

Death related to the adverse event