Category | Term | PValue | Genes | |
GOTERM_CC_DIRECT | GO:0005654~nucleoplasm | 65 | 1.32E−06 | KIF23, XRCC3, PRPF4B, AURKAIP1, IFI44L, FOXO3, MIOS, TIA1, RNF38, PMS2, ATF7IP, SYMPK, SRPK2, CGRRF1, HNRNPA2B1, ARHGAP27, MBNL1, ISG20L2, PARP10, ARID1B, TOX4, ZFR, RPTOR, SLTM, USP28, YME1L1, CLOCK, ADD1, ZNF436, NEK7, IQCB1, PFKFB3, PEAK1, TFE3, ELK3, SCRIB, ECD, NFAT5, BCL9L, MAML3, NDRG2, SNAP23, BUB3, TRIP12, PRPF40A, ZMYM1, KLF12, PPHLN1, PHB, ZMYM5, ILF3, HNRNPDL, STAT3, SFMBT2, COG3, MEF2D, CBLB, SRSF4, NSMF, HNRNPH1 |
KEGG_PATHWAY | bta05169:Epstein-Barr virus infection | 14 | 1.65E−06 | PIK3CG, BOLA, TRAF2, FCER2, MGC126945, STAT3, TYK2, AKT1, MAPK9, PIK3R5, RBPJ, ENTPD1, EIF2AK2 |
KEGG_PATHWAY | bta05160:Hepatitis C | 13 | 3.29E−05 | AKT1, PIK3CG, TYK2, TRAF2, IKBKE, RXRA, MAPK9, PIK3R5, OAS2, EIF2AK2, STAT3, EIF2AK4, NR1H3 |
GOTERM_MF_DIRECT | GO:0005524~ATP binding | 54 | 2.14E−04 | ABCF1, KIF23, XRCC3, TARS2, ERCC6L2, PRPF4B, STK36, ACSS3, PRKX, AKT1, PMS2, SRPK2, YARS, WNK1, MINK1, LOC100299180, TBCK, CDKL4, MAST3, TYK2, SCYL1, ATP2C1, HIPK2, MAPK9, YME1L1, EIF2AK2, EIF2AK4, NEK7, STK16, PFKFB4, PFKFB3, GLUD1, PEAK1, OAS1Z, TRIB3, CHEK2, OAS2, CHD9, IGF1R, ERCC6, PIKFYVE, LMTK2, CHD6, ENTPD1, TEC, LOC523126, TAOK3, MET, RIMKLA, ATM, IKBKE, LOC522174, NLRP12, JAK2 |
KEGG_PATHWAY | bta05168:Herpes simplex infection | 14 | 2.67E−04 | TRAF1, TYK2, TRAF2, BOLA, IKBKE, SRSF4, MAPK9, JAK2, OAS2, EIF2AK2, MGC126945, EIF2AK4, CLOCK |
GOTERM_BP_DIRECT | GO:0002474~antigen processing and presentation of peptide antigen via MHC class I | 5 | 2.89E−04 | BOLA |
GOTERM_CC_DIRECT | GO:0042612~MHC class I protein complex | 5 | 2.91E−04 | BOLA |
KEGG_PATHWAY | bta04152:AMPK signaling pathway | 11 | 2.92E−04 | AKT1, PIK3CG, IGF1R, PFKFB4, TSC1, PFKFB3, PPP2R5C, PIK3R5, FOXO3, RPTOR, CPT1A |
GOTERM_BP_DIRECT | GO:0090630~activation of GTPase activity | 8 | 0.001115995 | RALGAPA2, NDEL1, TSC1, TBC1D9, RASGRP1, TBC1D5, SCRIB, TBCK |
GOTERM_MF_DIRECT | GO:0003676~nucleic acid binding | 26 | 0.001231736 | RALY, ZKSCAN7, KLF7, ZNF469, ZBTB47, ERCC6L2, SETD1B, ZNF142, EXD2, ZNF655, HNRNPDL, ZNF177, ZNF333, PNLDC1, ZNF32, LOC100124497, ZNF783, ZNF383, THOC7, CELF2, ZNF462, CHD6, ZNF575, ZNF484, ZNF572, ZNF436 |
KEGG_PATHWAY | bta05164:Influenza A | 12 | 0.001450005 | AKT1, TYK2, PIK3CG, IKBKE, NUP98, LOC784541, MAPK9, JAK2, PIK3R5, OAS2, EIF2AK2, EIF2AK4 |
GOTERM_MF_DIRECT | GO:0044822~poly(A) RNA binding | 38 | 0.001518466 | RALY, ABCF1, BCLAF1, PRPF4B, HMGN2, RPS15A, HELZ, ANKRD17, TIA1, MRPL54, UBAP2L, TNRC6B, FNDC3B, DUS3L, PRPF40A, SRPK2, YARS, ARHGEF1, ZC3H7A, PPHLN1, RBM12B, RPL26, ILF3, ISG20L2, MBNL1, HNRNPDL, ZFR, SLTM, SRSF4, LARP4, LRP1, NCOA5, RPP25L, HNRNPH1, EIF2AK2, ADD1, SUPT6H, GOLGB1 |
KEGG_PATHWAY | bta04611:Platelet activation | 10 | 0.001864725 | AKT1, PIK3CG, ARHGEF1, RASGRP1, PLA2G4F, PIK3R5, SNAP23, ARHGEF12, ITGB1, ITGA2B |
KEGG_PATHWAY | bta04210:Apoptosis | 7 | 0.002292729 | AKT1, PIK3CG, TRAF2, CASP7, LOC784541, PIK3R5, ATM |
KEGG_PATHWAY | bta04015:Rap1 signaling pathway | 13 | 0.00259339 | AKT1, PIK3CG, IGF1R, RASGRP3, MRAS, MET, SIPA1L3, PIK3R5, PDGFD, THBS1, ITGB1, RGS14, ITGA2B |
GOTERM_CC_DIRECT | GO:0036064~ciliary basal body | 8 | 0.002743578 | AKT1, CYLD, WRAP73, KIFAP3, PCM1, WHRN, RTTN, SPATA7 |
GOTERM_MF_DIRECT | GO:0005096~GTPase activator activity | 13 | 0.003435645 | TBC1D9, SIPA1L3, RGS19, OCRL, RIC8B, TBCK, RGS14, RALGAPA2, RASGRP3, RABEP1, STXBP5, TBC1D5, ARHGDIB |
KEGG_PATHWAY | bta04330:Notch signaling pathway | 6 | 0.003519254 | DTX4, PSEN1, APH1B, NOTCH4, MAML3, RBPJ |
GOTERM_BP_DIRECT | GO:0022027~interkinetic nuclear migration | 3 | 0.004070538 | CEP120, PCM1, HOOK3 |
GOTERM_BP_DIRECT | GO:0016477~cell migration | 10 | 0.004185454 | TYK2, TNS3, CLN3, NDEL1, PEAK1, JAK2, THBS1, BRAT1, SCRIB, PRPF40A |
KEGG_PATHWAY | bta04920:Adipocytokine signaling pathway | 7 | 0.004542899 | AKT1, TRAF2, RXRA, MAPK9, JAK2, CPT1A, STAT3 |
GOTERM_BP_DIRECT | GO:0006511~ubiquitin-dependent protein catabolic process | 9 | 0.004798544 | CYLD, USP28, USP40, USP11, USP20, USP37, USP25, USP42, TTC3 |
KEGG_PATHWAY | bta04917:Prolactin signaling pathway | 7 | 0.005568078 | AKT1, PIK3CG, MAPK9, JAK2, PIK3R5, FOXO3, STAT3 |
GOTERM_CC_DIRECT | GO:0005813~centrosome | 18 | 0.005605498 | IQCB1, KIF23, MBNL1, CEP85L, PCM1, RIC8B, RGS14, RTTN, PCGF5, CYLD, ODF2L, G6PD, NDEL1, PSEN1, WRAP73, KIFAP3, USP20, NDRG2 |
GOTERM_CC_DIRECT | GO:0005801~cis-Golgi network | 5 | 0.006078583 | COG3, SCYL1, ANGEL1, GOLGB1, HOOK3 |
GOTERM_BP_DIRECT | GO:2000323~negative regulation of glucocorticoid receptor signaling pathway | 3 | 0.006665319 | CRY2, PHB, CLOCK |
GOTERM_MF_DIRECT | GO:0004843~thiol-dependent ubiquitin-specific protease activity | 7 | 0.008398196 | CYLD, USP28, USP11, USP20, USP37, USP25, USP42 |
GOTERM_MF_DIRECT | GO:0003725~double-stranded RNA binding | 6 | 0.009206343 | TARBP2, OAS1Z, ILF3, MBNL1, OAS2, EIF2AK2 |
KEGG_PATHWAY | bta04380:Osteoclast differentiation | 9 | 0.009224883 | AKT1, TYK2, PIK3CG, TRAF2, CYLD, MITF, MAPK9, PIK3R5, TEC |
KEGG_PATHWAY | bta04150:mTOR signaling pathway | 6 | 0.009304827 | AKT1, PIK3CG, TSC1, PIK3R5, RICTOR, RPTOR |
GOTERM_BP_DIRECT | GO:0035455~response to interferon-alpha | 3 | 0.009823125 | EIF2AK2, MX2, KLHL20 |
KEGG_PATHWAY | bta04910:Insulin signaling pathway | 9 | 0.01004313 | AKT1, PIK3CG, CBLB, SORBS1, TSC1, PPP1R3F, MAPK9, PIK3R5, RPTOR |
GOTERM_CC_DIRECT | GO:0005737~cytoplasm | 103 | 0.010610664 | XRCC3, TARS2, HMGN2, METTL21A, XPO6, STK36, SNCA, PRKX, LNX1, TRIM47, LOC515551, RNF38, PMS2, MX2, PIK3CG, YARS, HNRNPA2B1, EXD2, ARID1B, RIC8B, TACC1, TNS3, RALGAPA2, LYST, MGA, CELF2, DCUN1D3, ZNF436, STK16, SETD1B, PEAK1, TFE3, TTC3, SH3BP5L, NDRG2, PRPF40A, ZMYM1, KLF12, ZMYM5, TAOK3, ARFIP1, RIMKLA, ATE1, HDAC5, CBLB, NSMF, SMURF1, RBPJ, HNRNPH1, PLEKHA2, CREBRF, ABCF1, DPH3, AKT1, ANKRD17, RMND5A, CASP7, DPP8, MICAL1, TUBB1, NRG1, KLHL20, ATF7IP, SYMPK, SRPK2, ARHGEF2, EGR2, ARHGEF1, LPGAT1, FBXL20, MINK1, ARHGAP27, KCTD20, ARHGEF12, KLHDC3, TYK2, TARBP2, USP28, HIPK2, THOC7, SIAH1, UBB, TPM3, NDC1, IGF1R, CHD9, ECD, NFAT5, TRIP12, SHMT2, UPF2, USP40, RCAN3, TTC17, BRAT1, STAT3, RGS14, MEF2D, ATXN7, SAMD9, NLRP12, JAK2, RNF111 |
KEGG_PATHWAY | bta04931:Insulin resistance | 8 | 0.010979344 | AKT1, PIK3CG, MAPK9, TRIB3, PIK3R5, CPT1A, STAT3, NR1H3 |
GOTERM_BP_DIRECT | GO:0046777~protein autophosphorylation | 9 | 0.012710802 | STK16, IGF1R, PEAK1, TAOK3, LMTK2, MINK1, CHEK2, EIF2AK2, PRKX |
GOTERM_BP_DIRECT | GO:0070536~protein K63-linked deubiquitination | 4 | 0.013113229 | CYLD, SHMT2, USP20, USP25 |
GOTERM_BP_DIRECT | GO:0043406~positive regulation of MAP kinase activity | 5 | 0.013368446 | PIK3CG, PSEN1, RASGRP1, PIK3R5, PDGFD |
GOTERM_CC_DIRECT | GO:0005794~Golgi apparatus | 24 | 0.014210482 | RNF144A, CLCN3, CPTP, NDST2, PPHLN1, OSBPL9, MINK1, CHEK2, PARP10, DSE, GLCE, HOOK3, HDAC5, LOC515551, PSEN1, SCYL1, ATP2C1, KIFAP3, RASGRP1, GOLGA1, LMTK2, NDRG2, SLC30A6, GOLGB1 |
KEGG_PATHWAY | bta04014:Ras signaling pathway | 12 | 0.014339951 | AKT1, PIK3CG, IGF1R, RASGRP3, MRAS, RASGRP1, NF1, MET, MAPK9, PLA2G4F, PIK3R5, PDGFD |
GOTERM_BP_DIRECT | GO:0035556~intracellular signal transduction | 15 | 0.015816518 | SRPK2, ARHGEF2, ARHGEF6, ASB12, WNK1, ARHGEF12, RGS14, MAST3, TYK2, SH3BP5L, AKT1, PSEN1, PIKFYVE, NRG1, TEC |
KEGG_PATHWAY | bta04510:Focal adhesion | 11 | 0.016201172 | AKT1, PIK3CG, IGF1R, MET, MAPK9, PIK3R5, PDGFD, THBS1, ITGB1, PARVB, ITGA2B |
GOTERM_CC_DIRECT | GO:0015630~microtubule cytoskeleton | 7 | 0.016532829 | SHMT2, TAF1A, LYST, ATXN7, PMS2, TACC1, SPTAN1 |
GOTERM_BP_DIRECT | GO:0045071~negative regulation of viral genome replication | 4 | 0.017309895 | SRPK2, ILF3, PARP10, EIF2AK2 |
GOTERM_BP_DIRECT | GO:0001921~positive regulation of receptor recycling | 3 | 0.017702846 | PSEN1, SNCA, SCRIB |
KEGG_PATHWAY | bta04810:Regulation of actin cytoskeleton | 11 | 0.018272634 | PIK3CG, ARHGEF1, ARHGEF6, MRAS, PIKFYVE, PIK3R5, PDGFD, ARHGEF12, ITGB1, FGD3, ITGA2B |
KEGG_PATHWAY | bta04514:Cell adhesion molecules (CAMs) | 9 | 0.020016292 | BOLA, CD80, SELL, CD274, CD6, ITGB1, MGC126945, LOC616254 |
GOTERM_CC_DIRECT | GO:0048471~perinuclear region of cytoplasm | 18 | 0.020196784 | XRCC3, SEC24A, SNCA, OAS2, TPD52, ANGEL1, TARBP2, CYLD, RASGRP3, PIKFYVE, LMTK2, GOLGA1, USP20, PUM2, NDRG2, EIF2AK2, DCUN1D3, KLHL20 |
KEGG_PATHWAY | bta04151:PI3K-Akt signaling pathway | 15 | 0.020322244 | PIK3CG, RXRA, PPP2R5C, MET, FOXO3, ITGB1, RPTOR, AKT1, IGF1R, TSC1, JAK2, PIK3R5, PDGFD, THBS1, ITGA2B |
GOTERM_BP_DIRECT | GO:0017148~negative regulation of translation | 5 | 0.021050278 | TSC1, TIA1, ILF3, EIF2AK2, SAMD4B |
GOTERM_BP_DIRECT | GO:0031532~actin cytoskeleton reorganization | 5 | 0.022851943 | PHACTR1, ATP2C1, MINK1, RICTOR, PARVB |
KEGG_PATHWAY | bta04068:FoxO signaling pathway | 8 | 0.026066228 | AKT1, PIK3CG, IGF1R, MAPK9, PIK3R5, FOXO3, ATM, STAT3 |
GOTERM_MF_DIRECT | GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 11 | 0.027075777 | MEF2D, EGR2, FOXJ2, TFE3, MITF, NFAT5, TEF, ELK3, RBPJ, STAT3, NR1H3 |
GOTERM_BP_DIRECT | GO:0015012~heparan sulfate proteoglycan biosynthetic process | 3 | 0.027472207 | NDST2, DSE, GLCE |
GOTERM_BP_DIRECT | GO:0007040~lysosome organization | 4 | 0.0307095 | TMEM106B, LYST, HOOK3, CLN6 |
GOTERM_CC_DIRECT | GO:0090575~RNA polymerase II transcription factor complex | 4 | 0.030828201 | RXRA, HIPK2, STAT3, NR1H3 |
KEGG_PATHWAY | bta04668:TNF signaling pathway | 7 | 0.031389763 | TRAF1, AKT1, PIK3CG, TRAF2, CASP7, MAPK9, PIK3R5 |
GOTERM_BP_DIRECT | GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 8 | 0.032191499 | RNF144A, RMND5A, SIAH1, SMURF1, TRIP12, KLHL20, RNF111, LNX1 |
GOTERM_BP_DIRECT | GO:0050768~negative regulation of neurogenesis | 3 | 0.0329965 | ARHGEF2, PCM1, HOOK3 |
KEGG_PATHWAY | bta05166:HTLV-I infection | 12 | 0.033073932 | AKT1, PIK3CG, BOLA, ATF3, EGR2, MRAS, PIK3R5, CHEK2, MGC126945, ATM, BUB3 |
KEGG_PATHWAY | bta04550:Signaling pathways regulating pluripotency of stem cells | 8 | 0.033273587 | AKT1, PIK3CG, IGF1R, PCGF5, JARID2, JAK2, PIK3R5, STAT3 |
GOTERM_CC_DIRECT | GO:0005769~early endosome | 9 | 0.03349405 | CLN3, CLCN3, DYSF, DERL1, PHB, ZFYVE16, LMTK2, OCRL, ANKFY1 |
GOTERM_CC_DIRECT | GO:0005884~actin filament | 5 | 0.035775146 | TSC1, WIPF2, FKBP15, WHRN, TPM3 |
GOTERM_MF_DIRECT | GO:0000166~nucleotide binding | 14 | 0.037351839 | RALY, RBM12B, SETD1B, HNRNPA2B1, G3BP2, HNRNPDL, RCAN3, SLTM, SRSF4, LARP4, TIA1, CELF2, TNRC6B, HNRNPH1 |
GOTERM_BP_DIRECT | GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process | 8 | 0.037767923 | RMND5A, PPP2R5C, RNF38, SIAH1, SMURF1, CLOCK, KLHL20, RNF111 |
KEGG_PATHWAY | bta05145:Toxoplasmosis | 7 | 0.037943926 | AKT1, TYK2, IL10RA, MAPK9, JAK2, ITGB1, STAT3 |
GOTERM_BP_DIRECT | GO:0035023~regulation of Rho protein signal transduction | 6 | 0.03814075 | ARHGEF2, ARHGEF1, ARHGEF6, ARHGEF12, FGD3, ARHGDIB |
GOTERM_MF_DIRECT | GO:0046872~metal ion binding | 41 | 0.038963827 | PDP1, ZKSCAN7, ZNF469, HELZ, OAS2, DPH3, ZNF177, CNOT7, ITGB1, ZNF32, LOC100124497, ZFYVE16, POLM, ASPH, PHF20L1, ZNF575, FGD3, DUS3L, KLF7, ARHGEF2, ZBTB47, EGR2, ZC3H7A, KLF12, ADNP, ZNF142, MBNL1, ZNF333, RIMKLA, HDAC5, PPM1D, ZNF783, ZNF383, PLA2G4F, ZNF462, ZC3H11A, ANKFY1, KDM6B, ZNF484, ZNF572, ZNF436 |
GOTERM_CC_DIRECT | GO:0005640~nuclear outer membrane | 3 | 0.039013613 | CPTP, PSEN1, LTC4S |
GOTERM_BP_DIRECT | GO:0008283~cell proliferation | 9 | 0.039588703 | USP28, USPL1, ECD, YME1L1, BRAT1, APPL2, TACC1, STAT3, SCRIB |
KEGG_PATHWAY | bta04012:ErbB signaling pathway | 6 | 0.040508847 | AKT1, PIK3CG, CBLB, MAPK9, PIK3R5, NRG1 |
GOTERM_BP_DIRECT | GO:0045494~photoreceptor cell maintenance | 4 | 0.040731561 | IQCB1, PROM1, ERCC6, SPATA7 |
GOTERM_CC_DIRECT | GO:0000781~chromosome, telomeric region | 4 | 0.040884325 | SMC6, THOC7, CHEK2, ATM |
KEGG_PATHWAY | bta04144:Endocytosis | 11 | 0.041417674 | IGF1R, BOLA, CBLB, FOLR2, RABEP1, ZFYVE16, WIPF2, SMURF1, MGC126945, ARAP1 |
GOTERM_MF_DIRECT | GO:0008270~zinc ion binding | 35 | 0.042579019 | TRAF1, TRAF2, SEC24A, SNCA, TTC3, LNX1, PCGF5, TRIM47, CYLD, TRIM6, RASGRP1, PIKFYVE, RNF38, CDADC1, MICAL1, ZDHHC20, KDM5C, NR1H3, RNF144A, DTX4, CGRRF1, ZMYM1, RXRA, ZMYM5, ZFR, CBLB, PHF3, KDM2B, PHF21A, USP20, SIAH1, KAT6B, ZFHX2, RERE, RNF111 |
GOTERM_MF_DIRECT | GO:0031490~chromatin DNA binding | 5 | 0.045301309 | RXRA, JMJD1C, FOXO3, STAT3, CLOCK |
KEGG_PATHWAY | bta04071:Sphingolipid signaling pathway | 7 | 0.048497673 | AKT1, PIK3CG, TRAF2, PPP2R5C, MAPK9, PIK3R5, NSMAF |
GOTERM_BP_DIRECT | GO:0016579~protein deubiquitination | 5 | 0.051735245 | USP28, USP40, USP11, USP20, USP42 |
GOTERM_CC_DIRECT | GO:0012506~vesicle membrane | 3 | 0.051954441 | TRAF2, CLCN3, PIKFYVE |
GOTERM_CC_DIRECT | GO:0031519~PcG protein complex | 3 | 0.051954441 | PCGF5, KDM2B, UBAP2L |
GOTERM_BP_DIRECT | GO:0032026~response to magnesium ion | 2 | 0.052393136 | SNCA, THBS1 |
GOTERM_MF_DIRECT | GO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding | 9 | 0.053461677 | ZMYM1, FOXJ2, SNAPC4, PHB, ZMYM5, FOXJ3, FOXO3, ELK3, FOXS1 |
GOTERM_MF_DIRECT | GO:0004674~protein serine/threonine kinase activity | 11 | 0.057021302 | MAST3, AKT1, STK16, SRPK2, PRPF4B, HIPK2, WNK1, LMTK2, CHEK2, NEK7, CDKL4 |
KEGG_PATHWAY | bta04722:Neurotrophin signaling pathway | 7 | 0.057046106 | AKT1, PIK3CG, PSEN1, MAPK9, PIK3R5, FOXO3, ARHGDIB |
KEGG_PATHWAY | bta04145:Phagosome | 8 | 0.059172835 | BOLA, PIKFYVE, ATP6V1H, TUBB1, THBS1, ITGB1, MGC126945 |
KEGG_PATHWAY | bta04664:Fc epsilon RI signaling pathway | 5 | 0.059404884 | AKT1, PIK3CG, MAPK9, PLA2G4F, PIK3R5 |