Variable | Univariate | Multivariate Multivariate | ||
HR (95% CI) | p | HR (95% CI) | p | |
Age at diagnosis >64 years ≤64 years |
1.086 (0.654 - 1.801) 1 | 0.751 |
1.289 (0.765 - 2.173) 1 | 0.340 |
Sex Male Female |
0.848 (0.458 - 1.568) 1 | 0.599 |
1.253 (0.653 - 2.402) 1 | 0.498 |
Tumor site Oral and pharynx Larynx |
1.836 (1.063 - 3.169) 1 | 0.029 |
1.650 (0.880 - 3.092) 1 | 0.118 |
Differentiation Moderate and poor Well |
1.11 (0.66 - 1.869) 1 | 0.694 |
0.705 (0.401 - 1.238) 1 | 0.223 |
T stage T3,4 T1,2 |
1.43 (0.85 - 2.408) 1 | 0.178 |
1.239 (0.701 - 2.189) 1 | 0.461 |
Nodal status N+ N0 |
3.022 (1.809 - 5.049) 1 | 0.000 |
2.301 (1.231 - 4.304) 1 | 0.009 |
VEGF-A High > 2.74 Low ≤ 2.74 |
1.932 (1.161 - 3.215) 1 | 0.011 |
1.435 (0.807 - 2.553) 1 | 0.219 |
Ki-67 High > 58.61 Low ≤ 58.61% |
1.744 (1.05 - 2.898) 1 | 0.032 |
1.559 (0.929 - 2.615) 1 | 0.093 |
Combined expression Both high Either high Neither high |
2.987 (1.569 - 5.687) 1.241 (0.665 - 2.314) 1 | 0.001 0.498 |
2.357 (1.14 - 4.873) 1.187 (0.559 - 2.353) 1 | 0.021 0.624 |