Variable

Univariate

Multivariate Multivariate

HR (95% CI)

p

HR (95% CI)

p

Age at diagnosis

>64 years

≤64 years

1.086 (0.654 - 1.801)

1

0.751

1.289 (0.765 - 2.173)

1

0.340

Sex

Male

Female

0.848 (0.458 - 1.568)

1

0.599

1.253 (0.653 - 2.402)

1

0.498

Tumor site

Oral and pharynx

Larynx

1.836 (1.063 - 3.169)

1

0.029

1.650 (0.880 - 3.092)

1

0.118

Differentiation

Moderate and poor

Well

1.11 (0.66 - 1.869)

1

0.694

0.705 (0.401 - 1.238)

1

0.223

T stage

T3,4

T1,2

1.43 (0.85 - 2.408)

1

0.178

1.239 (0.701 - 2.189)

1

0.461

Nodal status

N+

N0

3.022 (1.809 - 5.049)

1

0.000

2.301 (1.231 - 4.304)

1

0.009

VEGF-A

High > 2.74

Low ≤ 2.74

1.932 (1.161 - 3.215)

1

0.011

1.435 (0.807 - 2.553)

1

0.219

Ki-67

High > 58.61

Low ≤ 58.61%

1.744 (1.05 - 2.898)

1

0.032

1.559 (0.929 - 2.615)

1

0.093

Combined expression

Both high

Either high

Neither high

2.987 (1.569 - 5.687)

1.241 (0.665 - 2.314)

1

0.001

0.498

2.357 (1.14 - 4.873)

1.187 (0.559 - 2.353)

1

0.021

0.624