Variable | Univariate | Multivariate | ||||
p value | HR | 95% CI | p value | HR | 95% CI | |
Age | 0.122 | 0.982 | 0.960 - 1.005 | 0.011 | 0.964 | 0.937 - 0.992 |
Sex | 0.822 | 0.945 | 0.575 - 1.552 |
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Grade of malignancy |
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High (reference group) |
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Intermediate | <0.0001 | 0.297 | 0.154 - 0.573 | 0.003 | 0.316 | 0.149 - 0.671 |
Low | <0.0001 | 0.211 | 0.107 - 0.414 | 0.010 | 0.335 | 0.146 - 0.769 |
Visceral metastases | 0.196 | 1.400 | 0.841 - 2.333 | 0.290 | 1.374 | 0.763 - 2.476 |
Number of metastases |
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Single (reference group) |
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Two | 0.971 | 0.981 | 0.341 - 2.822 |
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Multiple | 0.242 | 1.473 | 0.769 - 2.822 |
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Presentation of metastases | 0.011 | 1.965 | 1.164 - 3.316 | 0.329 | 1.385 | 0.720 - 2.663 |
Pathological fracture | 0.622 | 1.133 | 0.690 - 1.861 |
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Surgery | 0.022 | 0.554 | 0.335 - 0.918 |
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Systemic therapy | 0.017 | 0.544 | 0.330 - 0.898 | 0.031 | 0.531 | 0.299 - 0.943 |