Variable

Univariate

Multivariate

p value

HR

95% CI

p value

HR

95% CI

Age

0.122

0.982

0.960 - 1.005

0.011

0.964

0.937 - 0.992

Sex

0.822

0.945

0.575 - 1.552

Grade of malignancy

High (reference group)

Intermediate

<0.0001

0.297

0.154 - 0.573

0.003

0.316

0.149 - 0.671

Low

<0.0001

0.211

0.107 - 0.414

0.010

0.335

0.146 - 0.769

Visceral metastases

0.196

1.400

0.841 - 2.333

0.290

1.374

0.763 - 2.476

Number of metastases

Single (reference group)

Two

0.971

0.981

0.341 - 2.822

Multiple

0.242

1.473

0.769 - 2.822

Presentation of metastases

0.011

1.965

1.164 - 3.316

0.329

1.385

0.720 - 2.663

Pathological fracture

0.622

1.133

0.690 - 1.861

Surgery

0.022

0.554

0.335 - 0.918

Systemic therapy

0.017

0.544

0.330 - 0.898

0.031

0.531

0.299 - 0.943