Variable | Univariate | Multivariate | ||||
p value | HR | 95% CI | p value | HR | 95% CI | |
Age | 0.701 | 1.004 | 0.983 - 1.026 |
|
|
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Sex | 0.391 | 1.257 | 0.745 - 2.119 |
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|
|
Grade of malignancy |
|
|
|
|
|
|
Low (reference group) |
|
|
|
|
|
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Intermediate | 0.007 | 2.623 | 1.302 - 5.283 | 0.026 | 2.345 | 1.108 - 4.962 |
High | <0.0001 | 3.784 | 1.894 - 7.557 | 0.012 | 2.958 | 1.270 - 6.891 |
Visceral metastases | 0.514 | 1.187 | 0.709 - 1.988 |
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|
|
Number of metastases |
|
|
|
|
|
|
Single (reference group) |
|
|
|
|
|
|
Two | 0.166 | 2.752 | 0.657 - 11.524 |
|
|
|
Multiple | 0.295 | 1.591 | 0.667 - 3.793 |
|
|
|
Presentation of metastases | 0.046 | 1.752 | 1.009 - 3.041 | 0.517 | 1.250 | 0.636 - 2.457 |
Pathological vertebral fracture | 0.645 | 0.787 | 0.283 - 2.184 |
|
|
|
Surgery | 0.003 | 0.164 | 0.049 - 0.548 |
|
|
|
Systemic therapy | 0.007 | 0.484 | 0.285 - 0.822 | 0.215 | 0.698 | 0.395 - 1.232 |