Variable

Univariate

Multivariate

p value

HR

95% CI

p value

HR

95% CI

Age

0.701

1.004

0.983 - 1.026

Sex

0.391

1.257

0.745 - 2.119

Grade of malignancy

Low (reference group)

Intermediate

0.007

2.623

1.302 - 5.283

0.026

2.345

1.108 - 4.962

High

<0.0001

3.784

1.894 - 7.557

0.012

2.958

1.270 - 6.891

Visceral metastases

0.514

1.187

0.709 - 1.988

Number of metastases

Single (reference group)

Two

0.166

2.752

0.657 - 11.524

Multiple

0.295

1.591

0.667 - 3.793

Presentation of metastases

0.046

1.752

1.009 - 3.041

0.517

1.250

0.636 - 2.457

Pathological vertebral fracture

0.645

0.787

0.283 - 2.184

Surgery

0.003

0.164

0.049 - 0.548

Systemic therapy

0.007

0.484

0.285 - 0.822

0.215

0.698

0.395 - 1.232