Variable

Univariate

Multivariate

p value

HR

95% CI

p value

HR

95% CI

Age

0.741

0.997

0.979 - 1.016

Sex

0.773

1.063

0.701 - 1.612

Grade of malignancy

High (reference group)

Intermediate

0.003

0.457

0.273 - 0.764

0.011

0.478

0.271 - 0.844

Low

<0.0001

0.306

0.175 - 0.533

0.011

0.420

0.215 - 0.822

Visceral metastases

0.481

1.162

0.766 - 1.763

Number of metastases

Single (reference group)

Two

0.937

0.962

0.369 - 2.507

Multiple

0.367

1.298

0.737 - 2.286

Presentation of metastases

0.014

1.741

1.116 - 2.715

0.314

1.299

0.780 - 2.164

Pathological fracture

0.728

1.077

0.710 - 1.634

Surgery

0.003

0.527

0.344 - 0.808

Systemic therapy

0.002

0.505

0.330 - 0.772

0.041

0.618

0.389 - 0.982