Variable | Univariate | Multivariate | ||||
p value | HR | 95% CI | p value | HR | 95% CI | |
Age | 0.741 | 0.997 | 0.979 - 1.016 |
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Sex | 0.773 | 1.063 | 0.701 - 1.612 |
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Grade of malignancy |
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|
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High (reference group) |
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|
|
|
|
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Intermediate | 0.003 | 0.457 | 0.273 - 0.764 | 0.011 | 0.478 | 0.271 - 0.844 |
Low | <0.0001 | 0.306 | 0.175 - 0.533 | 0.011 | 0.420 | 0.215 - 0.822 |
Visceral metastases | 0.481 | 1.162 | 0.766 - 1.763 |
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Number of metastases |
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|
|
|
|
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Single (reference group) |
|
|
|
|
|
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Two | 0.937 | 0.962 | 0.369 - 2.507 |
|
|
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Multiple | 0.367 | 1.298 | 0.737 - 2.286 |
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|
|
Presentation of metastases | 0.014 | 1.741 | 1.116 - 2.715 | 0.314 | 1.299 | 0.780 - 2.164 |
Pathological fracture | 0.728 | 1.077 | 0.710 - 1.634 |
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|
|
Surgery | 0.003 | 0.527 | 0.344 - 0.808 |
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|
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Systemic therapy | 0.002 | 0.505 | 0.330 - 0.772 | 0.041 | 0.618 | 0.389 - 0.982 |