Primary Outcome

AUC

Trough

P-value

Primary Composite

31/51 (60.8)

44/90 (48.9)

0.04

Leukocytosis resolution

13/17(76.5%)

23/30(76.7%)

1.0

Fever resolution

3/17 (17.6%)

4/30 (13.3%)

0.7

Culture clearance

15/17 (88.2%)

17/30 (56.7%)

0.03