| Major Features | Minor Features |
| Facial angiofibromas or forehead plaque Nontraumatic ungual or periungual fibroma Hypomelanotic macules (more than three) Shagreen patch (connective tissue nevus) Cortical tuber* Subependymal nodule Subependymal giant cell astrocytoma Multiple retinal nodular hamartomas Cardiac rhabdomyoma Lymphangiomyomatosis Renal angiomyolipoma | Multiple randomly distributed pits in dental enamel Hamartomatous rectal polyps Bone cysts Cerebral white-matter “migration tracts” Gingival fibromas Nonrenal hamartoma Retinal achromic patch “Confetti” skin lesions Multiple renal cysts |