| Major events | Minor manifestations | Evidence of strep infection |
| Cardites | Fièvre Fever | High and increasing level of anti-treptococcal antibodies (Aslo, Dnase B) |
| Polyarthritis | Arthralgia | |
| Chorea | Elongation of space PR on electrocardiogram | Positive pharyngeal cultures or identification by rapid strep test or recent scarlet fever |
| Erythema marginatum | ||
| Subcutaneous nodules | Non-specific inflammatory signs (raised ESR, CRP, gammaglobilins) |