P

X2

Arm 2 WBRT only

Arm1 irinotecan and WBRT

Variables

>0.05

NS

0.6

57.1 + 9

55.6 + 10

Age (mean + SD)

(ECOG P S)

>0.05

NS

0.2

6 (24%)

5 (20%)

0

15 (60%)

15 (60%)

1

4 (16%)

5 (20%)

2

>0.05

NS

1.2

16 (64%)

9 (36%)

15 (60%)

10 (40%)

Gender

Male

Female

>0.05

NS

4

5 (20%)

7 (28%)

Primary tumor Breast

15 (60%)

14 (56%)

Lung

2 (8%)

1 (4%)

Melanoma

1 (4%)

1 (4%)

Colon

0

1 (4%)

Parotid

0

1 (4%)

Unknown

1 (4%)

0

HCC

1 (4%)

0

Ovary

Number of brain metastases

>0.05

NS

2.2

2 (8%)

0

1

2 (8%)

2 (8%)

2

2 (8%)

3 (12%)

3

19 (76%)

20 (80%)

>3

extracerebral metastasis

>0.05

NS

12 (48%)

10 (40%)

No

13 (52%)

15 (60%)

Yes

previous chemotherapy

(>0.05 NS

12 (48%)

9 (36%)

No

13 (52%)

16 (64%)

Yes