Characteristics

No. of tumors examined

WT

KRAS mutation

(%)

p

Total

103

11

(11)

Age (mean)

67.0

68.3

Gender

Male

74

64

10

(14)

Female

29

28

1

(3)

NS

Smoking status

Never

26

25

1

(4)

Ex-smoker

26

23

3

(12)

Current

51

44

7

(14)

NS

Smoking index

<799

46

42

4

(9)

>800

57

50

7

(12)

NS

Histological differentiation

Adenocarcinoma

69

63

6

(9)

NS

Squamous cell ca.

26

24

2

(8)

Adenosquamous ca.

2

1

1

(50)

LCNEC

6

4

2

(33)

Patholoical stage

I

51

47

4

(8)

NS

II

27

22

5

(19)

III

22

20

2

(8)

IV

3

3

0

(0)

CADM1 genes

Methylated

45

41

4

(9)

NS

Unmethylated

58

51

7

(12)

EGFR

Mutated

11

11

0

(0)

p < 0.05

Not mutated

92

65

27

(32)

CADM1 gene

Methylated

45

41

4

(9)

NS

Unmethylated

58

51

7

(12)

4.1B gene

Methylated

59

51

8

(14)

NS

Unmethylated

44

41

3

(7)

CADM1 or 4.1B gene

Both or either methylated

71

62

9

(13)

NS

Both unmethylated

32

30

2

(6)