Characteristics

No. of tumors examined

WT

EGFR mutation

(%)

p

Total

103

76

27

(26)

Age (mean)

67.0

3.2

63.8

Gender

Male

74

64

10

(14)

Female

29

12

17

(59)

<0.00001

Smoking status

Never

26

10

16

(65)

Ex-smoker

26

20

6

(23)

Current

51

46

5

(12)

<0.00001

Smoking index

<799

46

23

23

(54)

>800

57

53

4

(7)

<0.000001

Histological differentiation

Adenocarcinoma

69

42

27

(41)

<0.0001

Squamous cell ca.

26

26

0

(0)

Adenosquamous ca.

2

2

0

(0)

6

6

0

(0)

Adenocarcinoma

69

42

27

(41)

Histological differentiation

Well differentiated

22

10

12

(55)

Moderately diff.

37

22

15

(41)

p < 0.05

Poorly differentiated

10

10

0

(0)

Patholoical stage

I

36

21

15

(42)

NS

II

13

8

5

(38)

III

17

10

7

(41)

IV

3

3

0

(0)

KRAS gene

Mutated

11

11

0

(0)

Not mutated

92

65

27

(32)

p < 0.05

CADM1 gene

Methylated

45

37

8

(18)

Unmethylated

58

39

19

(33)

NS

4.1B gene

Methylated

59

47

12

(20)

Unmethylated

44

29

15

(34)

NS

CADM1 or 4.1B gene

Both or either methylated

71

55

16

(23)

Both unmethylated

32

21

11

(34)

NS