Items

General group

(87 cases)

Severe group

(34 cases)

X²/t

P

Gender

0.425

0.671

Male (cases)

77 (88.51%)

31 (91.17%)

Female (cases)

10 (11.49%)

3 (8.83%)

Age (years)

44.34±13.81

43.94±10.99

0.168

0.867

Weight (kg)

51.23±9.63

52.57±8.61

0.745

0.459

Types of common fungal infections

Candida (case)

29 (33.33%)

16 (47.09%)

1.398

0.162

Talaromyces marneffei(cases)

30 (34.48%)

7 (20.59%)

1.485

0.138

Cryptococcus (cases)

11 (12.64%)

1 (2.94%)

1.598

0.110

Amphotericin B dose

Less than 25 mg (cases)

5 (5.75%)

3 (8.82%)

0.610

0.542

25mg (cases)

77 (88.51%)

25 (73.52%)

2.027

0.043

More than 25 mg (cases)

5 (5.75%)

6 (17.65%)

2.038

0.042

Main types of adverse reactions

Leucopenia (cases)

5 (5.75%)

7 (20.59%)

2.445

0.014

Drug fever (cases)

2 (2.30%)

5 (14.71%)

2.612

0.009

Hypokalemia (cases)

24 (27.59%)

15 (44.12%)

1.742

0.082

Abnormal liver function (cases)

14 (16.09%)

6 (17.65%)

0.206

0.837

Impairment of renal function (cases)

38 (34.48%)

10 (29.41%)

1.436

0.151

Time of adverse reaction after use

Within 1 week (cases)

46 (52.87%)

16 (47.09%)

0.573

0.567

1 to 2 weeks (cases)

29 (33.33%)

13 (38.23%)

0.507

0.621

More than 2 weeks (cases)

12 (13.79%)

5 (14.71%)

0.129

0.897

Reaction of drug withdrawal and drug reduction

Reduce or disappear (cases)

56 (64.37%)

28 (82.35%)

1.922

0.055

Drug reduction without stopping (cases)

20 (22.99%)

3 (8.82%)

1.778

0.075

Unknown (cases)

11 (12.64%)

3 (8.82%)

0.588

0.556

Course of the disease

6.799

<0.001

Not obvious (cases)

67 (77.01%)

3 (8.82%)

Extension (cases)

20 (22.99%)

31 (91.18%)

Outcome

Recovery

21 (24.14%)

8 (23.53%)

0.070

0.944

Improvement (cases)

55 (63.22%)

20 (58.82%)

0.446

0.646

No improvement (cases)

1 (1.15%)

4 (11.76%)

2.626

0.009

Unknown (cases)

10 (11.49%)

2 (5.88%)

0.924

0.355