Samples

Agent

MIC/MBC (μg/mL)

FIC/FBC

FICI/ FBCI²

Outcome

Alone

Combination¹

MSSA ATCC 25923³

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

8/16

2/4

0.25/0.25

MRSA ATCC 33591⁴

Fucoidan

128/512

32/64

0.25/0.125

0.375/0.25

Synergistic/Synergistic

Ampicillin

1024/2048

128/256

0.125/0.125

MRSA 1⁵

Fucoidan

64/256

16/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

1024/2048

256/512

0.25/0.25

MRSA 2

Fucoidan

128/512

32/128

0.25/0.25

0.75/0.75

Additive/Additive

Ampicillin

128/256

64/128

0.5/0.5

MRSA 3

Fucoidan

256/1024

64/256

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

1024/2048

256/512

0.25/0.25

MRSA 4

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

256/512

64/128

0.25/0.25

MRSA 5

Fucoidan

64/128

16/64

0.25/0.5

0.5/0.75

Synergistic/Additive

Ampicillin

128/256

32/64

0.25/0.25

MRSA 6

Fucoidan

64/256

16/64

0.25/0.25

0.5/0.75

Synergistic/Additive

Ampicillin

256/256

64/128

0.25/0.5

MRSA 7

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

128/512

32/128

0.25/0.25

MRSA 8

Fucoidan

64/128

16/32

0.25/0.25

0.75/0.5

Additive/Synergistic

Ampicillin

128/256

64/64

0.5/0.25

MRSA 9

Fucoidan

128/512

32/128

0.25/0.25

0.75/0.5

Additive/Synergistic

Ampicillin

128/512

64/128

0.5/0.25

MRSA 10

Fucoidan

64/128

16/32

0.25/0.25

0.5/0.75

Synergistic/

Additive

Ampicillin

64/128

16/64

0.25/0.5

MRSA 11

Fucoidan

128/512

32/64

0.25/0.125

0.5/0.375

Synergistic/

Synergistic

Ampicillin

128/256

32/64

0.25/0.25

MRSA 12

Fucoidan

256/1024

64/128

0.25/0.125

0.5/0.625

Synergistic/Additive

Ampicillin

256/256

64/128

0.25/0.5

MRSA 13

Fucoidan

512/2048

128/256

0.25/0.125

0.375/0.375

Synergistic/Synergistic

Ampicillin

32/64

4/16

0.125/0.25

MRSA 14

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

128/256

32/64

0.25/0.25

MRSA 15

Fucoidan

64/256

16/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

64/128

16/32

0.25/0.25

MRSA 16

Fucoidan

128/512

64/128

0.5/0.25

0.75/0.5

Additive/

Synergistic

Ampicillin

128/256

32/64

0.25/0.25

MRSA 17

Fucoidan

64/128

16/64

0.25/0.5

0.5/0.75

Synergistic/Additive

Ampicillin

128/256

32/64

0.25/0.25

MRSA 18

Fucoidan

64/256

16/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Ampicillin

64/128

16/32

0.25/0.25

MRSA 19

Fucoidan

64/256

16/64

0.25/0.25

0.5/0.5

Synergistic/

Synergistic

Ampicillin

64/128

16/32

0.25/0.25

MRSA 20

Fucoidan

256/1024

64/128

0.25/0.125

0.75/0.375

Additive/Synergistic

Ampicillin

128/512

64/128

0.5/0.25