Samples

Agent

MIC/MBC (μg/mL)

FIC/FBC

FICI/ FBCI²

Outcome

Alone

Combination¹

MSSA ATCC 25923³

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

0.25/1

0.0625/0.25

0.25/0.25

MRSA ATCC 33591⁴

Fucoidan

128/512

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 1⁵

Fucoidan

64/256

32/64

0.5/0.25

1.0/0.5

Additive/Synergistic

Oxacillin

16/32

8/8

0.5/0.25

MRSA 2

Fucoidan

128/512

32/64

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 3

Fucoidan

256/1024

64/256

0.25/0.25

0.5/0.5

Synergistic/

Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 4

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 5

Fucoidan

64/128

16/64

0.25/0.5

0.75/0.75

Additive/

Additive

Oxacillin

16/32

8/8

0.5/0.25

MRSA 6

Fucoidan

64/256

16/32

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 7

Fucoidan

128/256

64/128

0.5/0.5

0.75/0.625

Additive/

Additive

Oxacillin

64/256

16/32

0.25/0.125

MRSA 8

Fucoidan

64/128

16/32

0.25/0.25

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/32

2/4

0.25/0.125

MRSA 9

Fucoidan

128/512

32/128

0.25/0.25

0.5/0.75

Synergistic/Additive

Oxacillin

16/32

4/16

0.25/0.5

MRSA 10

Fucoidan

64/128

16/32

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 11

Fucoidan

128/512

32/64

0.25/0.125

0.375/0.25

Synergistic/Synergistic

Oxacillin

16/64

2/8

0.125/0.125

MRSA 12

Fucoidan

256/1024

64/128

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

32/64

8/16

0.25/0.25

MRSA 13

Fucoidan

512/2048

128/256

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

32/64

8/16

0.25/0.25

MRSA 14

Fucoidan

128/256

32/64

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 15

Fucoidan

64/256

16/32

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 16

Fucoidan

128/512

64/128

0.5/0.25

0.75/0.75

Additive/Additive

Oxacillin

16/32

4/16

0.25/0.5

MRSA 17

Fucoidan

64/128

16/32

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 18

Fucoidan

64/256

16/32

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/32

2/8

0.25/0.25

MRSA 19

Fucoidan

64/256

16/32

0.25/0.125

0.75/0.625

Additive/Additive

Oxacillin

8/16

4/8

0.5/0.5

MRSA 20

Fucoidan

256/1024

64/128

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25