Drug

Dose

Response time in sec

Reaction time in min

0 min

15 min

30 min

45 min

60 min

Group 1

-

4.3 ± 0.50

4.0 ± 0.80

3.8 ± 0.50

5.3 ± 0.96

4.0 ± 0.80

Group 2

MLE

150 mg/kg

2.8 ± 0.50^*

4.3 ± 0.50^*

3.5 ± 1.00^*

4.3 ± 0.96^*

4.9 ± 0.90^*

Group 3

MLE

250 mg/kg

2.6 ± 0.50^*

3.5 ± 1.00^*

4.8 ± 1.30^*

4.1 ± 0.90^*

4.0 ± 0.01^*

Group 4

MLE

350 mg/kg

3.1 ± 0.30^*

4.3 ± 0.50^*

4.0 ± 0.80^*

4.4 ± 1.10^*

4.1 ± 0.90^*