Concentration in supernatant (ng/mL)

Compounds

Glucose

(mM)

Normal mice

Acatalasemic mice

Control (5)

Alloxan (3)

Control (6)

Alloxan (4)

Insulin

3

10.6 ± 3.3

5.6 ± 1.9

6.6 ± 1.8

5.7 ± 1.9

Insulin

20

27.0 ± 7.0

7.5 ± 2.5**

12.0 ± 0.2

4.0 ± 2.0**

C-peptide

3

15.3 ± 5.8

10.9 ± 3.7

19.0 ± 4.1

10.8 ± 6.3

C-peptide

20

37.0 ± 10.0

16.0 ± 8.0**

33.0 ± 0.02

8.0 ± 6.0**