COMPARISM of PARAMETERS BETWEEN RADIOTHERAPY, RADIOSURGERY AND RADIOLYSIS

PARAMETERS

RADIOTHERAPY

RADIO-SURGERY

RADIOLYSIS

Objective

Tumor regression

Aneurismal fibrosis

Regression of keloidal mass

Target cell tissue

Malignant cells

Aneurysmal walls

Keloidal collagen

Primary target

Blood vessel

Secondary target

BED of target cells/tissues

Low-normoxic

High

Not applicable

High Hypoxic

Connective tissue

Biologically innate

Ground substances

Alpha/beta of targeted cells/tissue

Dependent

Independent

Independent

Oxygenation

Dependent

Independent

Independent

Cycling fraction

Dependent

Independent

Independent

Fractionation

Dependent

Independent (?)

Independent

Fraction size

Dependent

Dependent

Independent

Impact of quality radiation

Dependent

No data

No data

Impact of radio-sensitizers

Positive on hypoxic cells

No data

No data

End point

Tumor resolution

Obliteration of aneurysmal cavity

1). Inhibition of post-operative recurrence

2). Keloid resolution