Treatment

Tail response time (Seconds)

0 min (T0)

30 min (T1)

60 min (T2)

T1 − T0

T2 − T0

Distilled water 10 ml/kg

(Negative Control)

PBAE 100 mg/kg

PBAE 200 mg/kg

PBAE 400 mg/kg

Morphine 2 mL/kg

Positive Control)

1.14 ± 0.04

1.14 ± 0.04

1.11 ± 0.03

1.14 ± 0.02

1.18 ± 0.03

1.18 ± 0.04a

1.49 ± 0.10*

1.13 ± 0.05a,b

1.21 ± 0.05

1.31 ± 0.07a,b

1.18 ± 0.02

1.68 ± 0.18*,c

1.44 ± 0.10*,c

1.84 ± 0.04*

2.00 ± 0.07*,c

0.45 ± 0.04d

0.36 ± 0.09*

0.02 ± 0.04*,d

0.06 ± 0.03*

0.12 ± 0.04*,d

0.04 ± 0.04

0.55 ± 0.18*,e

0.33 ± 0.11*,e

0.70 ± 0.04*,e

0.81 ± 0.09*,e