Outcome

Test^a

Reference^a

Ratio

90% LCL

90% UCL

p-value

AUC (hr*ng/mL)

ME Fasting

M + IE Fasting

67.8

56.8

81.0

0.0010

ME Fed

M + IE Fed

99.3

82.3

119.7

0.9483

ME Fasting

ME Fed

88.5

74.9

104.5

0.2175

M + IE Fasting

M + IE Fed

129.5

105.8

158.6

0.0414

Cmax (ng/mL)

ME Fasting

M + IE Fasting

66.2

54.8

79.8

0.0009

ME Fed

M + IE Fed

104.4

85.7

127.1

0.7148

ME Fasting

ME Fed

92.4

75.9

112.4

0.4879

M + IE Fasting

M + IE Fed

145.7

114.3

185.6

0.0164