Parameter

Basic model

Final model

Estimate (95% CI*)

% IIV (95% CI*)

Estimate (95% CI*)

% IIV (95% CI*)

CL/F§ (L/h/70kg)

14.3 (12.1 - 16.5)

60 (14.1 - 55.5)

Ka (h−1)

1.9 (1.0 - 4.0)

120 (59.3 - 260.1)

1.9 (1.0 - 4.4)

120 (59.0 - 280.0)

V/F (L/70kg)

597 (474.6 - 724.4)

56 (9.4 - 48.8)

580 (473.0 - 709.5)

62 (27.3 - 48.7)

Alag (h)

0.6 (0.4 - 0.8)

18 (1.3 - 24.5)

0.6 (0.3 - 0.8)

23 (1.2 - 38.5)

Bioª

1

26 (0.12 - 26.0)

-

-

σadd (%)

41 (34.7 - 47.5)

-

42 (37.2 - 45.7)

-