(N = 71)

(−1.8, −0.5)

EMPA 1 mg

90.6 ± 18.9

−1.6

-

(N = 71)

(−2.2, −0.9)

EMPA 5 mg

87.0 ± 14.8

−2.3^*

-

−71

(−2.9, −1.7)

EMPA 10 mg

87.9 ± 14.4

−2.7^**

-

(N = 71)

(−3.4, −2.1)

EMPA 25 mg

90.5 ± 16.9

−2.6^**

-

(N = 70)

(−3.2, −2.0)

EMPA 50 mg

91.6 ± 15.8

−2.9^***

-

(N = 70)

(−3.5, −2.2)

SITA

88.0 ± 15.0

−0.8

-

(N = 71)

(−1.5, −0.2)

^*p ≤ 0.01 vs. PBO

^**p ≤ 0.001 vs. PBO

^***p ≤ 0.0001 vs. PBO