Strojek (2011)	Randomized Double-blind Parallel-group Placebo- Controlled	592 T2DM (285M; 307F)	Open-label, Lead in Period: 8 weeks of GLIM daily Qualification Period: 1 week Double-blind Placebo-controlled Treatment Period: 24 weeks Group A: placebo before first meal of day + GLIM Group B: DAPA 2.5 mg daily before first meal of day + GLIM Group C: DAPA 5 mg daily before first meal of day + GLIM Group D: DAPA 10 mg daily before first meal of day + GLIM Extension Period: 24 weeks		HbA1C (%) at 24 Weeks
					Baseline Mean ± SD	Adjusted Mean Change	Difference vs. PBO (95% CI)
				PBO (N = 145)	8.15 ± 0.74	−0.13	-
				DAPA 2.5 mg (N = 154)	8.11 ± 0.75	−0.58	−0.44^*
							(−0.61, −0.27)
				DAPA 5 mg (N = 142)	8.12 ± 0.78	−0.63	−0.49^*
							(−0.67, −0.32)
				DAPA 10 mg (N = 151)	8.07 ± 0.79	−0.82	−0.68^*
							(−0.86, −0.51)
				^*p < 0.0001 vs. PBO at α = 0.019 applying Dunnett’s adjustment
					FPG (mg/dL) at 24 Weeks
					Baseline Mean ± SD	Adjusted Mean Change	Difference vs. PBO (95% CI)
				PBO (N = 145)	172.6 ± 37.3	−2	-
				DAPA 2.5 mg (N = 154)	172.3 ± 38.4	−16.8	−15
							(−21.8, −7.9)
				DAPA 5 mg (N = 142)	174.4 ± 38.2	−21.3	−19.3^*
							(−26.3, −12.3)
				DAPA 10 mg (N = 151)	172.1 ± 36.8	−28.5	−26.5^*
							(−33.5, −19.5)
				^*p < 0.0001 vs. PBO
					Body Weight (kg) at 24 Weeks
					Baseline Mean	Adjusted Mean Change	Difference vs. PBO (95% CI)
				PBO (N = 145)	80.94	−0.72	-
				DAPA 2.5 mg (N = 154)	81.89	−1.18	−0.46^*
							(−1.08, 0.15)
				DAPA 5 mg (N = 142)	81	−1.56	−0.84^**
							(−1.47, −0.21)
				DAPA 10 mg (N = 151)	80.56	−2.26	−1.54^***
							(−2.17, −0.92)
				^*p = 0.1410 vs. PBO
				^**p = 0.0091 vs. PBO (significant after sequential testing procedure at α = 0.05)
				^***p < 0.0001 vs. PBO (significant after sequential testing procedure at α = 0.05)
Bailey (2012)	Randomized Double-blind Parallel- group Placebo- controlled	282 T2DM (141M; 141F)	Qualification Period: 2 weeks Single-blind, Placebo Lead-in Period: 2 weeks		HbA1C (%) at 24 Weeks
					Baseline Mean ± SD	Adjusted Mean Change (95% CI)	Difference vs. PBO (95% CI)
				PBO (N = 68)	7.8 ± 1.12	0.02	-
						(−0.22, 0.25)
				DAPA 1 mg (N = 72)	7.8 ± 0.98	−0.68	−0.69^*