Author | Type of study | Conclusion |
Maniwa Y, et al. 1998 [47] | Clinical & Experimental | Disruption of angiogenesis suppression, induction of growth of dormant micro-metastasis due to post-op increase in VEGF |
Ikeda M, et al. 2002 [48] | Clinical | Peri-gastrectomy serum concentration of VEGF, sP-selectin, v WF, involved in angiogenesis, tumor-platelet adhesion, tumor-endothelial cell adhesion factors; surgical intervention enhanced tumor growth and metastasis |
Tagliabue E, et al. 2003 [49] | Clinical-operative specimen | HER2 over-expression by breast ca cells plays in post-surgery stimulation of growth of breast cancer cells |
Wu FP, et al. 2003 [50] | Prospective Patho-physio, Cancer v normal tissue, 16 specimens | Local VEGF increase & endostatin decrease; physiological response to surgery, with or without cancer |
Mitsudomi T, et al. 1996 [44] | Retrospective Clinical (197 cases) | Concluded residual tumor cells had accelerated growth after surgery |
Maffani MV, et al. 2004 [51] | Experimental | Important role of tumor stroma indicated; further extensive study recommended |
Maffani MV, et al. 2005 [52] | Experimental | Rat mammary gland tumor stroma prevents neoplastic development and encourage normal ductal growth from grafted epithelial cancer cells |