Author

Type of study

Conclusion

Gradishar W, et al. (2006) [2]

Analysis: multiple

prospective study

Sequential recommended: Tamoxifen & Anastozole Combo is better

Baum M, 1988 [3]

Global multi-centric prospective

Adjuvant Tamoxifen on pre & postmenopausal Advantage: No

comment on CON V SEQ

Pritchard KI, 2008 [14]

Review & Reflective

Hormone with chemo; CON V SEQ: yet a matter of debate

Albain K, et al. 2002 [15]

Prospective &

Randomized

Should be “sequenced not concurrent”

Pico C, et al. 2004 [16]

Trend in favor of

sequential

Trend in favor of sequential

Bedgonetti D, et al. 2011 [17]

Prospective &

Randomized

No diff: CON V SEQ: Poor statistical power

Del Mastro L, et al. 2008 [18]

Prospective &

Randomized

OS, DFS, Toxicity score: CON V SEQ = no difference Decreasing hazard of death-SEQ-group

Sideras K, 2010 [19]

Prospective &

Randomized

Post-menopausal node +, Oe + − > SEQ more effective

Early Breast Cancer Trialists

Collaborative Group (EBCTCG) 2005 [20]

Prospective &

Randomized

145,000 pt―15 yr FU

CT + SEQ Tam significantly better than CT + No Tam CON V

SEQ − not recorded