Mean (SD)

Median (Range)

OH

OL

TA

TAS

p-value

10 Minutes after the Application of the Spray

Subjective comfort

17.2 (19.2)

20.0 (−40 to 80)

16.2 (18.8)

20.0 (−30 to 80)

−6.8 (22.7)

0.0 (−85 to 50)

5.5 (18.0)

0.0 (−50 to 40)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Ocular redness

−0.04 (0.27)

0.00 (−1 to 1)

−0.04 (0.19)

0.00 (−1 to 0)

0.08 (0.26)

0.00 (0 to 1)

0.02 (0.15)

0.00 (0 to 1)

0.005

OH-TA 0.011

OH-TAS 0.095

OL-TA 0.003

OL-TAS 0.025

Bulbar and nasal conjunctival redness

−0.08 (0.19)

−0.05 (−0.60 to 0.50)

−0.07 (0.29)

−0.10 (−0.90 to 1.99)

0.12 (0.21)

0.00 (−0.50 to 0.70)

0.02 (0.16)

0.00 (−0.40 to 0.90)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

TBUT 1^st measurement

(seconds)

1.9 (6.7)

1.3 (−19.6 to 21.3)

2.7 (5.9)

2.7 (−22.1 to 23.2)

−1.0 (6.1)

−0.1 (−21.4 to 19.8)

0.5 (6.5)

0.6 (−20.4 to 19.8)

<0.001

OH-TA 0.002

OH-TAS 0.137

OL-TA < 0.001

OL-TAS 0.008

TBUT average

(seconds)

2.8 (5.8)

3.1 (−16.0 to 17.6)

3.8 (5.5)

4.2 (−14.4 to 19.3)

−1.0 (6.8)

−1.0 (−21.4 to 18.6)

0.2 (6.8)

0.1 (−17.3 to 17.7)

<0.001

OH-TA < 0.001

OH-TAS 0.005

OL-TA < 0.001

OL-TAS < 0.001

30 Minutes after the Application of the Spray

Subjective comfort

18.7 (19.6)

20.0 (−40 to 80)

17.1 (19.2)

20.0 (−30 to 80)

−4.2 (21.4)

0.0 (−50 to 70)

5.4 (17.7)

0.0 (−50 to 40)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Ocular redness

−0.06 (0.34)

0.00 (−1 to 1)

−0.09 (0.29)

0.00 (−1 to 0)

0.11 (0.35)

0.00 (−1 to 1)

0.04 (0.19)

0.00 (0 to 1)

<0.001

OH-TA 0.002

OH-TAS 0.031

OL-TA < 0.001

OL-TAS 0.001

Bulbar and nasal conjunctival redness

−0.14 (0.22)

−0.10 (−0.60 to 0.80)

−0.14 (0.25)

−0.10 (−0.60 to 1.29)

0.10 (0.31)

0.00 (−0.90 to 1.10)

0.00 (0.18)

0.00 (−0.50 to 0.90)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001