Mean (SD)

Median (Range)

OH

OL

TA

TAS

p-value

Subjective comfort

82.2 (16.9)

80.0 (20 to 100)

86.9 (16.3)

90.0 (20 to 100)

62.0 (21.7)

60 (20 to 100)

73.4 (22.4)

70.0 (20 to 100)

<0.001

OH-TA < 0.001

OH-TAS 0.010

OL-TA < 0.001

OL-TAS < 0.001

Ocular redness

0.4 (0.5)

0.0 (0 to 1)

0.2 (0.4)

0.0 (0 to 1)

0.4 (0.5)

0.0 (0 to 2)

0.4 (0.5)

0.0 (0 to 1)

0.043

OH-TA 0.214

OH-TAS 0.784

OL-TA 0.005

OL-TAS 0.052

Bulbar and nasal conjunctival redness

1.1 (0.5)

1.1 (0.0 to 2.1)

1.1 (0.5)

1.1 (0.2 to 2.1)

1.3 (0.6)

1.2 (0.3 to 2.5)

1.2 (0.5)

1.2 (0.3 to 2.2)

0.047

OH-TA 0.079

OH-TAS 0.241

OL-TA 0.012

OL-TAS 0.045

TBUT 1st measurement

(seconds)

12.1 (6.9)

9.5 (2.2 to 25.0)

11.4 (6.9)

9.4 (2.1 to 24.0)

6.5 (5.8)

4.4 (2.0 to 25.0)

7.2 (5.7)

5.4 (1.2 to 25.0)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

TBUT average

(seconds)

15.0 (5.7)

14.1 (2.7 to 25.0)

14.3 (5.7)

13.1 (3.5 to 24.0)

9.1 (5.5)

8.2 (2.0 to 25.0)

9.6 (5.5)

8.8 (2.0 to 25.0)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Smell

0.0 (0.2)

0.0 (0 to 1)

0.1 (0.3)

0.0 (0 to 2)

1.8 (1.6)

1.5 (0 to 5)

1.3 (1.4)

1.0 (0 to 5)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Application comfort

0.0 (0.0)

0.0 (0 to 0)

0.6 (5.6)

0.0 (0 to 50)

6.3 (14.7)

0.0 (0 to 60)

0.6 (3.2)

0.0 (0 to 20)

<0.001

OH-TA < 0.001

OH-TAS 0.078

OL-TA < 0.001

OL-TAS 0.352