Mean (SD)

Median (Range)

OH

OL

TA

TAS

p-value

Age

(years)

65.7 (16.9)

69.0 (19 to 93)

63.1 (17.5)

68.0 (18 to 93)

64.5 (18.1)

69.5 (19 to 93)

64.0 (16.3)

69.0 (18 to 90)

0.754

OSDI

16.7 (16.2)

13.0 (0 to 63)

14.7 (16.7)

8.0 (0 to 73)

17.5 (17.8)

12.5 (0 to 73)

14.0 (15.1)

8.0 (0 to 69)

0.412

Subjective comfort

63.4 (21.8)

60.0 (20 to 100)

69.8 (24.9)

70.0 (0 to 100)

66.2 (23.5)

70.0 (0 to 100)

68.0 (23.5)

70.0 (20 to 100)

0.200

Ocular redness

0.4 (0.6)

0.0 (0 to 2)

0.3 (0.5)

0.0 (0 to 1)

0.4 (0.5)

0.0 (0 to 2)

0.3 (0.5)

0.0 (0 to 1)

0.860

Bulbar and nasal conjunctival redness

1.3 (0.6)

1.2 (0.0 to 2.5)

1.2 (0.5)

1.2 (0.2 to 2.2)

1.2 (0.6)

1.1 (0.0 to 2.5)

1.2 (0.5)

1.2 (0.0 to 2.4)

0.781

TBUT 1st measurement

(seconds)

7.6 (5.8)

5.5 (1.2 to 25.0)

6.4 (5.3)

4.6 (0.8 to 25.0)

7.3 (5.7)

5.0 (1.2 to 24.0)

6.7 (5.7)

4.6 (1.2 to 25.0)

0.413

TBUT average

(seconds)

10.4 (5.7)

9.6 (2.2 to 25.0)

8.7 (5.3)

7.3 (1.9 to 25.0)

10.4 (6.2)

8.4 (2.3 to 24.0)

10.0 (5.9)

8.3 (1.3 to 25.0)

0.156

Smell

0.3 (0.6)

0.0 (0 to 3)

0.5 (0.8)

0.0 (0 to 3)

3.3 (1.7)

4.0 (0 to 5)

2.9 (1.5)

3.0 (0 to 5)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Application comfort

0.1 (1.1)

0.0 (0 to 10)

0.5 (2.7)

0.0 (0 to 20)

13.6 (20.7)

0.0 (0 to 80)

2.0 (7.4)

0.0 (0 to 40)

<0.001

OH-TA < 0.001

OH-TAS 0.026

OL-TA < 0.001

OL-TAS 0.210