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Foeniculum vulgare | Promotes the proliferation and differentiation of BM-derived hMSC into osteoblasts | Alaribe F N, | 2019 | [104] |
Ferula gummosa | Antibacterial effect Enhance proliferation and differentiation of BM-derived hMSCs into osteocytes. | Abbaszadegan A | 2015 | [105] |
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RUTTIN/ MORINDA citrifolia extract | Induction of osteogenic differentiation in human periodontal ligament cells Regulation of bone formation, improvement of chondrocytes cellularity Induction of cellular proliferation and matrix formation Enhancement of matrix mineralization Improvement in bone mechanical and physical properties/ Enhancement in osteogenic biomarkers expression Increases bone density | Zhao B, Min SK, Wan Osman WN, Zhao B, Gu H, Shalan NA, Hussain S | 2020 2020 2020 2020 2019 2019 2018 2017 2016 | [92] [174] [175] [185] [186] [176] [187] [188] [189] |
Fructus Ligustri Lucidi | Increases ALP activity, Increases the expression of osteogenesis-stimulating genes, osteoprotegerin | Ko. C Li. G | 2010 2009 | [113] [112] |
Cnidium monnieri/ Angelica pubescens Osthole | Induction of osteoclastogenesis: Enhancement in osteogenic activity Enhancement of bone healing and formation Enhancement of bone strength and fracture healing by through BMP2 signaling pathway Enhancement in bone formation rate, ALP activity, OCN and BMP2 expression | Zhao D, Zhang ZR, Sun J, Wang P, Zhang Z, Gao LN, | 2018 2017 2017 2017 2016 2013 | [190] [115] [116] [117] [118] [114] |
China Herba epimedii | Increases ALP activity and enhances mRNA expression of BMP-2, Runx2 (runt-related transcription factor 2), and OPN (osteopontin) | Zhang JF | 2009 | [119] |