STUDY

DRUGS

DOSE AND DURATION

BEFORE TREATMENT

AFTER TREATMENT

P VALUE

Haydardedeoglu (2009)

Palombo (2010)

Metformin + MPA

Metformin + folate

850 mg + 5 mg *3 months

1750 mg + 400 µg *6 months

12.82 ± 6.89

10.5 ± 3.9

14.66 ± 7.11

9.7 ± 4.2

0.111

<0.05