|
| A.A [Nucleotide] |
|
| Mutant frequency % (n) per year |
| |||
| Codon | Nucleotide | Wild type | Mutant | Type | N/S | 2016/2017 | 2018 | P-value |
| 125 | 375 | K [G] | K [A] | Trans | S | 50 (16) | 50 (16) | 6.3 × 10−20 |
| 100 | 299 | R [G] | K [A]* | Trans | N | 44.4 (18) | 55.6 (18) | 5 × 10−16 |
| 96 | 286 | D [G] | N [A] | Trans | N | 44.4 (18) | 55.6 (18) | 1 × 10−9 |
| 95 | 283 | E [G] | K [A] | Trans | N | 44.4 (18) | 55.6 (18) | 1 × 10−9 |
| 75 | 225 | S [T] | S [C] | Trans | S | 44.4 (18) | 55.6 (18) | 7.9 × 10−9 |
| 71 | 213 | K [G] | K [A] | Trans | S | 44.4 (18) | 44.4 (18) | 2 × 10−9 |
| 59 | 175 | E [G] | K [A] | Trans | N | 44.4 (18) | 55.6 (18) | 1 × 10−9 |
| 57 | 170 | R [G] | K [A] | Trans | N | 44.4 (18) | 55.6 (18) | 1.6 × 10−11 |
| 47 | 139 | V [G] | F [T] | Transv | N | 22.2 (18) | 44.4 (18) | 2.6 × 10−8 |
| 50 | 149 | G [G] | E [A] | Trans | N | 0 (18) | 11.1(18) |
|
| 81 | 243 | S [A] | S [T] | Transv | S | 0 (18) | 11.1(18) |
|
| 68 | 203 | I [T] | K [A] | Transv | N | 0 (18) | 11.1 (18) |
|
| 61 | 182 | Q [A] | P [C] | Transv | N | 0 (18) | 11.1 (18) |
|
| 60 | 180 | N [T] | N [C] | Transv | S | 0 (18) | 11.1 (18) |
|
| 149 | 447 | S [T] | S [G] | Transv | S | 50 (12) | 16.7 (12) |
|
| 179 | 537 | G [T] | G [A] | Transv | S | 50 (4) | 0 (4) |
|
| 156 | 466 | E [G] | K [A] | Trans | N | 50 (4) | 0 (4) |
|
| 158 | 474 | E [G] | E [A] | Trans | S | 0 (4) | 50 (4) |
|
| 183 | 547 | S [A]* | G [G] | Trans | N | 50 (4) | 50 (4) |
|
| 168 | 504 | K [G] | K [A] | Trans | S | 50 (4) | 50 (4) |
|
| 161 | 481 | A [G] | P [C] | Transv | N | 50 (4) | 50 (4) |
|
| 159 | 477 | K [G] | K [A] | Trans | S | 50 (4) | 50 (4) |
|