26

FT-IR (KBr, υ_max cm⁻¹): 3249, 3154 (2 NH), 3026, 2814 (CH), 1689 (C=O), 1283 (C=S). 1H NMR (DMSO-d6) δ ppm: 3.21 (s, 2H, CH₂), 6.79 - 7.79 (m, 6H, Ar-H and H-5 thiazole), 8.31 (s, 1H, NH exchanged by D₂O), 9.34 (s, 1H, NH exchanged by D₂O).

27

FT-IR (KBr, υ_max cm⁻¹): 3232, 3260, 3176 (NH), 1668 (C=O), 3053, 2990, 2873 (CH), 1242(C=S). 1H NMR (DMSO-d6) δ ppm: 6.95 - 7.31 (m, 10 H, Ar-H and H-5 thiazole), 7.50 - 7.90 (m, 4H, indole proton), 9.96 (s, 1H, =CH), 12.18 (s, 1H, NH exchanged by D₂O), 12.22 (s, 1H, NH exchanged by D₂O), 12.40 (s, 1H, NH exchanged by D₂O). ¹³C NMR (DMSO-d6) δ ppm: 185.37 (CS), 168 (CO), 155.46 (C=C), 166 (C-NH), 108.01, 112.01, 112.01, 113.74, 121.01, 123.44, 125.70, 127.62, 128.93, 129.01, 130.21, 130.8, 134.46, 135.88, 144.51, 146.01, 148.01.

28

FT-IR (KBr, υ_max cm ⁻¹): 3275 (NH), 1706 (C=O), 3037, 2988, 2817(CH). 1H NMR (DMSO-d6) δ ppm: 2.38 (s, 3H, CH₃), 7.31 - 7.35(m, 9H, Ar-H), 7.36 - 7.53 (m, 4H, indole proton and =CH), 7.82 (d, 1H, indole proton), 12.40 (s, 1H, NH exchanged by D₂O). ¹³C NMR (DMSO-d6) δ ppm: 12.58 (CH₃), 153(C=C), 160 (C=O), 108.82, 120.62, 120.74, 126.43, 126.63, 128.87, 129.07, 137.15, 140.16, 140.34. MS. m/z (%): 456 (M⁺, 1.9), 441 (0.3), 413 (0.4), 336 (3.4), 359 (48.1), 358 (100), 341 (62.3), 266 (20.3), 77 (92.7).

29a

FT-IR (KBr, υ_max, cm⁻¹): 3428, 3198 (NH), 3039, 2865(CH). 1H NMR (DMSO-d6) δ ppm: 2.26 (s, 3H, CH₃), 6.93 - 7.18 (m, 9H, Ar-H), 7.29 - 7.82 (m, 4H, indole proton), 8.04 (s, 1H, NH exchanged by D₂O), 11.56 (s, 1H, NH exchanged by D₂O).

29b

FT-IR (KBr, υ_max cm⁻¹): 3209 (NH), 3048, 2917, 2863 (CH). 1H NMR (DMSO-d6) δ ppm: 2.21 (s, 3H, CH₃), 6.93 - 7.32 (m, 14H, Ar-H), 7.37 - 7.82 (m, 4H, indole proton), 11.56 (s, 1H, NH exchanged by D₂O). MS. m/z (%): 544 (M⁺, 3.3), 529 (2.3), 467 (22.9), 375 (15.41), 295 (6.2), 298 (100), 273 (71.8), 271 (17.2).

30

FT-IR (KBr,υ_max cm⁻¹): 3323, 3174 (NH), 3055, 2969, 2864 (CH), 1242 (C= S). 1H NMR (DMSO-d6) δ ppm: 2.24 (s, 3H, CH₃), 2.28 (s, 3H, CH₃), 7.11 - 7.35 (m, 13H, Ar-H), 7.37 - 7.86 (m, 4H, indole proton), 11.48 (s, 1H, NH exchanged by D₂ O), 12.00 (s, 1H, NH exchanged by D₂O). MS. m/z (%): 617 (M⁺, 0.46), 587 (0.54), 522 (0.46), 467 (0.63), 414 (1.35), 330 (2.73), 252 (57.01), 125 (100).

31

FT-IR (KBr, υ_max, cm⁻¹): 3436 (NH), 3050, 2972, 2865 (CH), 1277 (C=S). 1H NMR (DMSO-d6) δ ppm: 2.28 (s, 3H, CH₃), 7.93 - 8.31 (m, 17H, Ar-H), 11.54 (s, 1H, NH exchanged by D₂O).