# | Experimental animal model | Cell type | Route of delivery | Important findings | Teratogenicity | Reference |
1 | Mice (adult wild-type mice) | hiPSC-derived fibroblasts | Direct injection into the sub-retinal space | Photoreceptors (retinal cells) | No teratomas were found following transplantation | Lamba et al., 2010 |
2 | Mouse model of contusive spinal cord injury | Safe iPSCs derived neurospheres | Direct injection into lesion epicenter | Neuronal differentiation | Safe iPSCs derived cells were non-teratogenic | Tsuji et al., 2010 |
3 | Hind-limb ischemia model of SCID mice by femoral artery ligation | hiPSC derived endothelial cells | Direct intramuscular injection | Increased capillary density and regional perfusion | No teratomas reported | Jalil et al., 2011 |
4 | Mouse model of acute coronary artery ligation | Skeletal myoblast derived iPSCs | Direct intra-myocardial injection | Angiomyogenesis with preserved heart function | 35% animals with iPSCs and no teratomas with progenitor cells | Ahmed et al., 2012 |
5 | Porcine model of myocardial infarction | hiPSCs | Catheter based I/M | Endothelial differentiation and neoangiogenesis | None until 12 - 15 weeks after transplantation | Templin et al., 2012 |
6 | Ischemic cardiomyopathy with ameroid ring | hiPSCs derived cardiomyocytes | Patch based delivery | Cardiomyogenesis with preserved LV remodeling and heart function | No teratogenicity during the course of studies | Kawamura et al., 2012 |
7 | Mouse model of acute coronary artery ligation | Mouse MSC-derived iPSCs or their derived cardiac progenitors. | Direct intra-myocardial injection | Angiomyogenesis with preserved heart function | 21% animals developed teratomas with iPSCs and no teratomas with progenitor cells | Buccini et al., 2012 |
8 | Mice (7- to 8-week-old female nude mice and immunodeficient mouse strains (nude, SCID, NOD-SCID and NOG) | Dermal fibroblast derived hiPSC | Direct subcutaneous injection | Retinal pigment epithelium | Negative after 15 months | Kanemura H et al., 2014 |