| ADE | Burzynski et al. 2015 Antineoplastons A10 and AS2-1 N (%) | Chamberlain et al. [31] 2006 Cyclophosphamide N (%) | Chamberlain et al. [32] 2008 CPT-11 N (%) | Yung et al. [22] 1999 Temozolomide N (%) | ||||
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | Grades 3/4 | Grade 5 | Grades 3/4 |
| |
| Hypernatremia | 5 (12.5) | 2 (5) |
|
|
|
|
|
|
| Hypocalcemia |
| 1 (2.5) |
|
|
|
|
|
|
| Hypokalemia | 4(10) | 2 (5) |
|
|
|
|
|
|
| Thrombocytopenia |
|
| 5 (12) | 1 (2) | 2 (5) |
| 10 (6) |
|
| Neutropenia |
|
| 7 (17) | 1 (2) | 1 (2) |
| 3 (2) |
|
| Leukopenia |
|
| 15 (37) | 2 (5) | 1 (2) |
| 3 (2) |
|
| Anemia |
|
| 5 (12) |
|
|
| 1 (1) |
|
| Asthenia |
|
|
|
| 2 (5) |
| 9 (6) |
|
| Fatigue | 1 (2.5) |
| 9 (22) |
|
|
| 7 (5) |
|
| Fever |
|
|
|
|
|
| 3 (2) |
|
| Peripheral edema |
|
|
|
|
|
| 1 (1) |
|
| Weight loss |
|
|
|
|
|
|
|
|
| Headache |
|
| 1 (2) |
|
|
| 10 (6) |
|
| Convulsions |
|
| 1 (2) |
|
|
| 8 (5) |
|
| Dizziness |
|
|
|
|
|
| 1 (1) |
|
| Somnolence | 1 (2.5) |
|
|
|
|
| 5 (3) |
|
| Suicide attempt |
|
|
|
|
|
|
|
|
| Pain | 1 (2.5) |
|
|
|
|
|
|
|
| Other neurological ADE* |
|
|
|
|
|
| 2 (1) |
|
| Hypertension |
|
|
|
|
|
|
|
|
| Syncope |
|
|
|
|
|
|
|
|
| Bradycardia |
|
|
|
|
|
|
|
|
| Apnea |
|
|
|
|
|
|
|
|
| Anorexia |
|
|
|
|
|
| 1 (1) |
|
| Constipation |
|
| 1(2) |
|
|
| 1 (1) |
|
| Diarrhea |
|
|
|
| 3 (7) | 1 (2) | 3 (2) |
|
| Nausea |
|
| 3 (7) |
| 2 (5) |
| 16 (10) |
|
| Vomiting |
|
| 2 (5) |
| 4 (10) |
| 10 (6) |
|
| Pruritus |
|
|
|
|
|
| 2 (1) |
|
| Infection |
|
| 1 (2) |
| 1 (2) |
|
|
|
| Thrombophlebitis |
|
| 1 (2) |
| 1 (2) |
|
|
|
| Intracranial hemorrhage |
|
|
|
|
|
|
|
|
| Bilirubinemia |
|
|
|
|
|
|
|
|
| Hyperglycemia |
|
|
|
|
|
|
|
|
| Urinary frequency | 1 (2.5) |
|
|
|
|
|
|
|
| Urticaria | 1 (2.5) |
|
|
|
|
|
|
|
| Basal cell carcinoma |
|
|
|
|
|
|
|
|