Parameter

2006 N = 239 N (%)

2011 N = 232 N (%)

p-value

Age (mean ± SD)

6.7 ± 4.8

6.8 ± 4.5

0.832

Day 7 evaluation

・ Fever

・ Recovery

103 (43)

136 (57)

145 (62)

87 (38)

˂0.001

Chemotherapy

・ Standard

・ Intensified

129 (54)

110 (46)

74 (32)

158 (68)

<0.001

Clinical infections

・ No

・ Yes

114 (48)

125 (52)

118 (51)

114 (49)

0.492

Organism

・ Gram positive cocci

・ Gram negative rods

・ Mixed

180 (75)

59 (25)

0 (0)

168 (72)

56 (24)

8 (4)

0.010

Antibiotic resistance

・ Sensitive

・ Resistant

147 (62)

92 (38)

113 (49)

119 (51)

0.005

Outcome

・ Alive

・ Dead

214 (90)

25 (10)

217 (94)

15 (6)

0.120