PK Parameter

Dose of Carboxyamidotriazole Orotate (CTO) Cohort/dose (mg/m²/day)

1 50

2 75

3 112.5

4 146.5

5 219

6 285

7 427

8 555

N

2

3

3

3

4

3

5

5

C_max,ss (ng/mL)

431 (67)

571 (34)

1160 (73)

1040 (16)

2370 (36)

1700 (61)

3450 (57)

3070 (46)

T_max^a (h)

4.25

4.0

2.0

4.0

5.0

4.0

2.0

2.0

AUC_0-8 (h∙ng/mL)

3170 (69)

4220 (34)

7810 (83)

7730 (19)

17,500 (38)

12,000 (66)

25,400 (57)

19,700 (45)