PK Parameter | Dose of Carboxyamidotriazole Orotate (CTO) Cohort/dose (mg/m2/day) | |||||||
1 50 | 2 75 | 3 112.5 | 4 146.5 | 5 219 | 6 285 | 7 427 | 8 555 | |
N | 3 | 3 | 4 | 4 | 10 | 3 | 8 | 9 |
Cmax (ng/mL) | 79.7 (39) | 173 (90) | 454 (58) | 414 (85) | 300 (68) | 616 (64) | 516 (56) | 632 (80) |
Tmaxa (h) | 36 | 32 | 16 | 16 | 24 | 8 | 24 | 24 |
AUC24h (h∙ng/mL) | 930 (36) | 2610 (100) | 6350 (52) | 7410 (86) | 4970 (53) | 11,500 (62) | 8690 (59) | 11,600 (79) |
AUC48h (h∙ng/mL) | 2640c (38) | 5160c (83) | 12,500c (57) | 15,200c (83) | ― | ― | ― | ― |
AUClast (h∙ng/mL) | ― | ― | ― | ― | 27,800d (45) | 35,000d (92) | 47,600d (53) | 54,000d (73) |
a, b (h) | ― | 35.9 | 37.4 ± 25 | 59.3 ± 22 | 66.7 ± 30 | 29.0 ± 10 | 50.7 ± 19 | 64.9 ± 36 |