PK Parameter

Dose of Carboxyamidotriazole Orotate (CTO) Cohort/dose (mg/m2/day)

1 50

2 75

3 112.5

4 146.5

5 219

6 285

7 427

8 555

N

3

3

4

4

10

3

8

9

Cmax (ng/mL)

79.7 (39)

173 (90)

454 (58)

414 (85)

300 (68)

616 (64)

516 (56)

632 (80)

Tmaxa (h)

36

32

16

16

24

8

24

24

AUC24h (h∙ng/mL)

930 (36)

2610 (100)

6350 (52)

7410 (86)

4970 (53)

11,500 (62)

8690 (59)

11,600 (79)

AUC48h (h∙ng/mL)

2640c (38)

5160c (83)

12,500c (57)

15,200c (83)

AUClast (h∙ng/mL)

27,800d (45)

35,000d (92)

47,600d (53)

54,000d (73)

a, b (h)

35.9

37.4 ± 25

59.3 ± 22

66.7 ± 30

29.0 ± 10

50.7 ± 19

64.9 ± 36