| Inclusion criteria | Exclusion criteria |
| 55 - 85 years people from both genders | Dementia diagnosis (according to DSM-IV, ICD-10 criteria) |
| MMSE > 25/30 | Neurological disorders (e.g. congenital and/or acquired metabolic encephalopathy, toxic and drug-induced encephalopathy; Parkinson disease, multi-infarct dementia, stroke, epilepsy, infectious diseases, demielinating and inherited neurodegenerative disorders, traumatic brain injury) |
| Subjective memory complains confirmed by close family member | Endocrine disorders, including decompensated diabetes |
| Objective signs of memory problems | Neoplasm |
| ADLs not overtly altered | HIV infection |
| Modified Hachinski Ischemic Scale (MIS) < 4, and Hamilton Depression Rating Scale (HDRS) < 18 at baseline | Mental disorders |
| 3rd stage Global Deterioration Scale (GDS) | Alcoholism and/or drug dependence |
| 0.5 score on Clinical Dementia Rating (CDR) | Drug induced or other intoxication |
| No clinical diagnosis of dementia | Folate or vitamin B12 deficiency |
| Signed Informed consent obtained | Systolic blood pressure > 180 mmHg, diastolic blood pressure > 95 mmHg |