Randomized Clinical Trials*

Was the study described as randomized?

Was the method used to generate the sequence of randomization described and appropriate?

Was there a description of random sequences concealment?

Was the method of random sequences concealment described and appropriate?

Was the study described as double-blind?

Was the method of double-blinding described and appropriate?

Was there a description of withdrawals and dropouts?

Total

Zhu et al. [25]

1

0

1

0

0

0

1

3

Nayan et al. [24]

1

0

1

0

0

0

1

3

Crehange et al. [22]

1

0

1

0

0

0

1

3

You et al. [18]

1

1

1

1

0

0

1

5

Hulshof et al. [20]

1

1

1

1

0

0

1

5

Xu et al. [19]

1

1

1

1

0

0

1

5

Non-randomized clinical trial**

Representative of Exposed Cohort

Selection of Non-Exposed Cohort

Ascertainment of Exposure

Demonstration That Outcome of Interest Was Not Present at Start of Study

Control for Important Factors

Additional Factors

Assessment of Outcome

Follow-Up

Adequacy of Follow-Up

Ma et al. [23]

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

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