Parameter

Group

AST (U/L)

ALT (U/L)

CK (U/L)

ckMB (U/L)

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Control

158.166 ± 14.031

-

0.428

71.00 ± 6.491

-

0.020^*

466.33 ± 100.02

-

0.295

160.33 ± 35.50

-

0.106

DOX

174.40 ± 11.075

0.428

-

108.60 ± 3.203

0.020^*

-

568.4 ± 68.92

0.295

-

56.40 ± 6.85

0.106

-

DOX pretreated with grape seed extract (GSPE)

202.42 ± 17.075

0.024^*

0.162

80.71 ± 12.050

0.493

0.068

481.57 ± 48.49

0.864

0.356

281.85 ± 34.59

0.043^*

0.001^*

DOX pretreated with Vitamin E

203.57 ± 13.232

0.021^*

0.146

79.857 ± 4.646

0.531

0.061

488.14 ± 59.80

0.806

0.393

319.71 ± 60.13

0.010^*

0.000^*

DOX pretreated with grape seed extract (GSPE) combined with Vitamin E

149.42 ± 6.931

0.641

0.211

86.00 ± 14.249

0.292

0.136

312.00 ± 25.97

0.090

0.010^*

148.57 ± 32.27

0.838

0.137