Parameter

Group

Total cholesterol (mg/dl)

LDL-c (mg/dl)

HDL-c (mg/dl)

Triglycerides (mg/dl)

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Control

70.80 ± 3.76

-

0.000^*

33.12 ± 2.31

-

0.000^*

25.20 ± 1.71

-

0.024^*

62.40 ± 3.51

-

0.013^*

DOX

108.33 ± 7.94

0.000^*

-

58.33 ± 5.42

0.000^*

-

30.83 ± 1.77

0.024^*

-

84.50 ± 6.53

0.013^*

-

DOX pretreated with grape seed extract (GSPE)

113.28 ± 2.51

0.000^*

0.427

63.61 ± 1.41

0.000^*

0. 240

33.28 ± 1.91

0.001^*

0.266

77.00 ± 4.80

0.080

0.334

DOX pretreated with Vitamin E

104.85 ± 3.29

0.000^*

0.576

57.62 ± 3.41

0.000^*

0. 874

31.71 ± 0.74

0.008^*

0.687

77.57 ± 5.81

0.069

0.372

DOX pretreated with grape seed extract (GSPE) combined with Vitamin E

87.28 ± 3.04

0.017^*

0.002^*

45.91 ± 4.56

0. 010^*

0. 009^*

26.85 ± 1.35

0.473

0.077

63.00 ± 5.23

0.941

0.009^*