One-step strategy: Perform a 75-g OGTT, with plasma glucose measurement when patient is fasting and at 1 and 2 h, at 24 - 28 weeks gestation in women not previously diagnosed with diabetes. The OGTT should be performed in the morning after an overnight fast of at least 8 h. The diagnosis of GDM is made when any of the following plasma glucose values are met or exceeded: · Fasting: 92 mg/dl (5.1 mmol/L) · 1 h: 180 mg/dl (10.0 mmol/L) · 2 h: 153 mg/dl (8.5 mmol/L) Two-step strategy: Step 1: Perform a 50-g GLT (nonfasting), with plasma glucose measurement at 1 h, at 24 - 28 weeks of gestation in women not previously diagnosed with diabetes. If the plasma glucose level measured 1 h after the load is ≥130, 135, or 140 mg/dl (7.2, 7.5, or 7.8 mmol/L, respectively), proceed to 100-g OGTT. Step 2: The 100-g OGTT should be performed when the patient is fasting. The diagnosis of GDM is made when at least two* of the following four plasma glucose levels (measured fasting and at 1, 2, and 3 h during OGTT) are met or exceeded (Carpenter-Coustan criteria [193]): · Fasting: 95 mg/dl (5.3 mmol/L) · 1 h: 180 mg/dl (10.0 mmol/L) · 2 h: 155 mg/dl (8.6 mmol/L) · 3 h: 140 mg/dl (7.8 mmol/L) |