Virus (HSV-1)

Name

Receptor

Detargeted from HVEM/ nectin-1

Mutations in gD (corresponding sites in Figure 3)

Conserved region in gD

Functional domain in gD

Motif in gD

Additional modification

Ref

Strain 17

R5111

IL13Rα2

-

gD: IL-13 inserted after AA24 (AA49)

None

Non- cytoplasmic domain

7

gC_Δ136-152: IL-13 replaced AA148;

gB_Δ68-77

[23]

Strain F

R5141

IL13Rα2

+

gD: Replaced aa 1-32 with IL-13(25-57)

None

Non- cytoplasmic domain

7

gB: Poly(K) deletion

gC: replaced the aa 1-132 with IL-13

[43]

Strain F

R5181

uPAR

-

gD: uPA inserted between AA 24 and 25 (AA49 and AA50)

None

Non- cytoplasmic domain

7

gC: N-terminal domain of

gC was replaced with IL-13

gB_Δ68-77

[55]

Strain F

R5322

uPAR

+

gDΔ1-32

mutations at AA 34, 38, 215, 222,

and 223 in gD, 62-218 deletion (gDΔ25-57,

mutation at

AA 59, 63,

240, 247

and 248 in

gD, 87-243 deletion)

1, 3-11

Non- cytoplasmic domain

1, 2, 4, 6, 7

None

[50]

Not mentioned

R-LM113

HER2

+

gD: replaced the AA 6-38 with scFv to HER2 (AA31-63)

1

Non- cytoplasmic domain

7

None

[56]

Not mentioned

R-LM249

HER2

+

gD: Replaced the AA 61-218 with scFv to HER2 (AA86-243)

3-11

Non- cytoplasmic domain

1, 2, 4, 6

None

[57]

Strain KOS

KGNEp

EpCAM

+

gD: Replaced the AA 2-24 with scFv to EpCAM (AA27-49)

None

Non- cytoplasmic domain

7

gB: a hyperactive allele, D285N/A549T (gB:NT).

[58]

Strain KOS

KNE (retargeted to EGFR) KNC

(retargeted to CEA)

EGFR

CEA

+

gD: Replaced the AA 2-24 with scFv to EGFR or CEA, and introduced the Y38C to ablate responsiveness

to nectin-1. (AA27-49)

None

Non- cytoplasmic domain

7

gB: D285N/A549T (gB:NT).

[59]