CAR

Factor

TCR

Single chain

Composition

Heterodimer

Surface antigen

Target

Peptide complex

Higher

Receptor affinity

Lower

Shorter (less than 2 min)

Required time to start

immune response

Longer (5 to 10 min)

Linked (2^nd and 3^rd generation)

Costimulation

Separated

Disorganized

Formation of immune synaps

Systematic bull’s eye structure

100 or less

Required number of Ag to recognize

1

Yes

Coreceptor

Yes

Yes

Serial Killing

Yes