Parameter

Oral administration

Intravenous infusion

100 mg

200 mg

400 mg

50 mg

100 mg

200 mg

AUC_0–∞ (μg·h/ml)

37.0 ± 6.75

78.5 ± 10.8

215 ± 42

11.3 ± 4.43

26.6 ± 6.25

73.2 ± 12.4

CL (liters/h)

2.8 ± 0.548

2.59 ± 0.363

1.91 ± 0.418

5.03 ± 1.99

3.69 ± 1.04

2.80 ± 0.519

t_1/2α (h)

1.70 ± 0.34

2.05 ± 0.53

2.06 ± 0.59

1.57 ± 0.52

1.53 ± 0.59

0.42 ± 0.31

t_1/2β (h)

36.1 ± 21.7

77.1 ± 12.8

56.0 ± 2.49

76.2 ± 32.0

104 ± 56.7

80.4 ± 33.0