Type of clinical adverse event (AE)

Patients

Number of patients with AE

Frequency of patients with AE (%)

General symptoms

Fatigue

4

5.71

Generalized pain

2

2.86

Chills

2

2.86

Thirst

1

1.43

Fever

1

1.43

Increased body temperature

1

1.43

Malaise

1

1.43

Ear, nose and throat

Rhinorrhea

5

7.14

Cough

4

5.71

Sneezing

3

4.29

Clearing of the throat

1

1.43

Eyes

Blurry vision

1

1.43

Neurologic

Headache

11

15.71

Psychiatric

Insomnia

1

1.43

Irritability

1

1.43

Skin

Rash

8

11.43

Generalized pruritus

2

2.86

Facial edema

1

1.43

Bones, joints and muscles

Arthralgia

3

4.26

Arthritis

2

2.86

Myalgia

1

1.43

Cardiopulmonary

Dyspnea

1

1.43

Tachycardia

1

1.43

Gastrointestinal

Nausea

1

1.43

Abdominal pain

1

1.43

Gynecology/Endocrine

Hot flashes

1

1.43

Polymenorrhea

1

1.43

Vaginal discharge

1

1.43

Other

Increased disease-related symptomatology

7

10

TOTAL

70

100