P. nigrum extracts/compounds

IC50 (µg・ml1) promastigotes (Mean ± SE)

IC50 (µg・ml1) amastigotes (Mean ± SE)

CC50 (µg・ml1) macrophages (Mean ± SE)

SI

PNH

31.6 ± 0.13

14.63 ± 1.58

379.7 ± 8.19

25.95

PNE

37.83 ± 2.58

18.33 ± 0.82

200 ± 1.69

10.91

PNA

>500

>500

-

-

Piperine

108.66 ± 1.96

41.33 ± 1.44

>500

-

Pentamidine

1.09 ± 0.055

0.84 ± 0.16

45.2 ± 2.86

53.80